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Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression

Glutathione has pleiotropic functions in different organs. Here the authors specifically examine deletion of a glutathione synthetic enzyme in the liver of adult mice and show that lack of glutathione affects lipid abundance through repressing NRF2.

Gloria Asantewaa
Emily T. Tuttle
Isaac S. Harris
ResearchOpen Access21 Jul 2024
Nature Communications

Volume: 15, P: 1-18
An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism

GPR61 is an orphan GPCR of interest for treatment of appetite disorders, such as obesity and cachexia. Here, the authors report structures of GPR61 in its active and inactive states, including with a G protein-competitive small molecule inverse agonist.

Joshua A. Lees
João M. Dias
Seungil Han
ResearchOpen Access23 Sept 2023
Nature Communications

Volume: 14, P: 1-12
CCR5 Expression and β-Chemokine Production During Placental Neonatal Monocyte Differentiation

Dylan Zylla
Yuan Li
Wen-Zhe Ho
Research01 May 2003
Pediatric Research

Volume: 53, P: 853-858
Epilepsy-causing sequence variations in SIK1 disrupt synaptic activity response gene expression and affect neuronal morphology

Christoph Pröschel
Jeanne N Hansen
Alex R Paciorkowski
Research14 Dec 2016
European Journal of Human Genetics

Volume: 25, P: 216-221
Autosomal recessive mutations in nuclear transport factor KPNA7 are associated with infantile spasms and cerebellar malformation

Alex R Paciorkowski
Judy Weisenberg
Bryce M Paschal
Research18 Sept 2013
European Journal of Human Genetics

Volume: 22, P: 587-593
Molecular analysis of aggressive renal cell carcinoma with unclassified histology reveals distinct subsets

A subset of renal cell carcinomas have uncertain histology and are aggressive in nature. Here, the authors examine this group of unclassified renal cancers using genomics techniques and identify further subclasses of the tumours that have differing prognoses.

Ying-Bei Chen
Jianing Xu
James J. Hsieh
ResearchOpen Access07 Oct 2016
Nature Communications

Volume: 7, P: 1-10
Incretin drugs in diabetic kidney disease: biological mechanisms and clinical evidence

Clinical trials have demonstrated that glucagon-like peptide 1 receptor (GLP1R) agonists have therapeutic benefits beyond glycaemic control. Here, the authors examine the protective effects of incretin-based therapies in patients with diabetic kidney disease and how the immunomodulatory and anti-inflammatory effects of GLP1 might underlie this protection.

Radica Z. Alicic
Emily J. Cox
Katherine R. Tuttle
Reviews20 Nov 2020
Nature Reviews Nephrology

Volume: 17, P: 227-244

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Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression

An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism

CCR5 Expression and β-Chemokine Production During Placental Neonatal Monocyte Differentiation

Epilepsy-causing sequence variations in SIK1 disrupt synaptic activity response gene expression and affect neuronal morphology

Autosomal recessive mutations in nuclear transport factor KPNA7 are associated with infantile spasms and cerebellar malformation

Molecular analysis of aggressive renal cell carcinoma with unclassified histology reveals distinct subsets

Incretin drugs in diabetic kidney disease: biological mechanisms and clinical evidence

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Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression

An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism

CCR5 Expression and β-Chemokine Production During Placental Neonatal Monocyte Differentiation

Epilepsy-causing sequence variations in SIK1 disrupt synaptic activity response gene expression and affect neuronal morphology

Autosomal recessive mutations in nuclear transport factor KPNA7 are associated with infantile spasms and cerebellar malformation

Molecular analysis of aggressive renal cell carcinoma with unclassified histology reveals distinct subsets

Incretin drugs in diabetic kidney disease: biological mechanisms and clinical evidence

Search

Quick links