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Showing 1–4 of 4 results
Advanced filters: Author: Emma M. Rath Clear advanced filters

  • Healthspan and healthy aging are areas of research with potential socioeconomic impact. Here, the authors present the Medical Genome Reference Bank (MGRB) which consist of over 4,000 individuals aged 70 years and older without a history of the major age-related diseases and report on results from whole-genome sequencing and association analyses.

    • Mark Pinese
    • Paul Lacaze
    • David M. Thomas
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • Transmission of influenza A viruses (IAV) between hosts and replication within host impose genetic bottlenecks, constraining viral diversity and adaptation. Here, Amato et al. perform site-specific inoculation of barcoded IAV of ferrets and track viral diversity as infection spreads to the lower respiratory tract and conclude that narrow population bottlenecks are an important feature of the within-host infection dynamics.

    • Katherine A. Amato
    • Luis A. Haddock III
    • Andrew Mehle
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • The majority of genetically targeted approaches to cancer therapy focus on somatic mutations. However, evidence is accumulating in support of a role for germline genetic alterations in determining responsiveness to treatment. In this Review, the authors summarize the therapeutic potential of knowledge of the germline genome in patients with cancer.

    • Subotheni Thavaneswaran
    • Emma Rath
    • David M. Thomas
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 16, P: 386-396