Nature Search

Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut

Metastasizing tumour cells undergo epithelial-to-mesenchymal transition. Using both bioinformatic and in vivo approaches, Chanrion et al.identify combined Notch activation and p53 inactivation as a potent inducer of this transition, and apply this to create a highly metastatic tumour model in mice.

Maia Chanrion
Inna Kuperstein
Sylvie Robine
ResearchOpen Access08 Oct 2014
Nature Communications

Volume: 5, P: 1-15
Coherent control of individual electron spins in a two-dimensional quantum dot array

Manipulation of multiple connected quantum objects is mandatory for any scalable quantum information platform. Based on finely tuned virtual gate control, the integration of nearest-neighbour coupled semiconductor quantum dots in a 3 × 3 array enables 2D coherent spin control.

Pierre-André Mortemousque
Emmanuel Chanrion
Tristan Meunier
Research21 Dec 2020
Nature Nanotechnology

Volume: 16, P: 296-301
Gate-based high fidelity spin readout in a CMOS device

Gate reflectometry on an ancillary dot coupled to an electron reservoir is used to read the spin of a qubit in a CMOS device in a single shot with an average fidelity above 98% within 0.5 ms.

Matias Urdampilleta
David J. Niegemann
Tristan Meunier
Research13 May 2019
Nature Nanotechnology

Volume: 14, P: 737-741
Distant spin entanglement via fast and coherent electron shuttling

On-chip, long-distance entanglement of spin qubits in semiconductors could enable connectivity of quantum core units for networked quantum computing. The moving trapping potential of a surface acoustic wave can subsequently displace two entangled spins while preserving entanglement over a separation of 6 μm.

Baptiste Jadot
Pierre-André Mortemousque
Tristan Meunier
Research15 Feb 2021
Nature Nanotechnology

Volume: 16, P: 570-575
Antibody-mediated neutralization of galectin-3 as a strategy for the treatment of systemic sclerosis

Galectin-3 (Gal-3) has been proposed to have a pathogenic role in systemic sclerosis (SSc). Here, the authors identify a Gal-3-based transcriptomic signature associated with SSc severity in patients and demonstrate that Gal-3 blockade reduces the severity of SSc skin and lung lesions in murine models.

Céline Ortega-Ferreira
Perrine Soret
Frédéric De Ceuninck
ResearchOpen Access31 Aug 2023
Nature Communications

Volume: 14, P: 1-20
Electrical manipulation of a single electron spin in CMOS using a micromagnet and spin-valley coupling

Bernhard Klemt
Victor Elhomsy
Matias Urdampilleta
ResearchOpen Access23 Oct 2023
npj Quantum Information

Volume: 9, P: 1-7
Systems medicine disease maps: community-driven comprehensive representation of disease mechanisms

Alexander Mazein
Marek Ostaszewski
Charles Auffray
ReviewsOpen Access02 Jun 2018
npj Systems Biology and Applications

Volume: 4, P: 1-10

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Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut

Coherent control of individual electron spins in a two-dimensional quantum dot array

Gate-based high fidelity spin readout in a CMOS device

Distant spin entanglement via fast and coherent electron shuttling

Antibody-mediated neutralization of galectin-3 as a strategy for the treatment of systemic sclerosis

Electrical manipulation of a single electron spin in CMOS using a micromagnet and spin-valley coupling

Systems medicine disease maps: community-driven comprehensive representation of disease mechanisms

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