Cyclodipeptide synthases hijack aminoacyl tRNAs to produce various cyclic dipeptides—the biosynthetic precursors of several secondary metabolites. Here, the authors solved the crystal structure of a cyclodipeptide synthase bound to a reaction intermediate analogue and provide novel insights into the mechanism of synthesis.
- Mireille Moutiez
- Emmanuelle Schmitt
- Muriel Gondry
