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Showing 1–3 of 3 results
Advanced filters: Author: Emmanuel Giudice Clear advanced filters

  • Trans-translation, mediated by small protein B (SmpB) and transfer-messenger RNA (tmRNA), enables recycling of the ribosomes stalled on defective mRNAs in bacteria. Here, the authors report structures of the ribosome during trans-translation that reveal a translocation intermediate and elucidate the movements of the tmRNA-SmpB complex in the ribosome.

    • Charlotte Guyomar
    • Gaetano D’Urso
    • Reynald Gillet
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • During eukaryotic ribosome biogenesis, the nascent 60S subunit is activated by SBDS and GTPase EFL1. Cryo-EM and mutational analyses reveal how SBDS–EFL1 evicts antiassociation factor eIF6 from 60S and explain the effects of disease-related SBDS mutations.

    • Félix Weis
    • Emmanuel Giudice
    • Alan J Warren
    Research
    Nature Structural & Molecular Biology
    Volume: 22, P: 914-919