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Showing 1–7 of 7 results
Advanced filters: Author: Emmanuel Karouzakis Clear advanced filters

  • Understanding the genetics of rheumatoid arthritis (RA) is complex, multiple genes and environmental factors are involved. A new multicentre genetic study summarizes the fundamental gene polymorphisms, pathways and cell types that are related to RA and, based on this analysis, proposes new targets for RA drug treatments.

    • Michel Neidhart
    • Emmanuel Karouzakis
    News & Views
    Nature Reviews Rheumatology
    Volume: 10, P: 199-200

  • Activated synovial fibroblasts have an important role in the destruction caused in rheumatoid arthritis. The aggressive phenotype of these cells is influenced by various epigenetic mechanisms, in particular DNA methylation. Improved understanding of these epigenetic alterations could inform the development of novel therapies for rheumatoid arthritis.

    • Emmanuel Karouzakis
    • Renate E. Gay
    • Michel Neidhart
    Reviews
    Nature Reviews Rheumatology
    Volume: 5, P: 266-272

  • The transcription factor PU.1 is an essential regulator of the pro-fibrotic gene expression program in fibroblasts; PU.1 expression is upregulated in various fibrotic diseases, whereas inactivation of PU.1 induces regression of fibrosis in a number of organs.

    • Thomas Wohlfahrt
    • Simon Rauber
    • Andreas Ramming
    Research
    Nature
    Volume: 566, P: 344-349

  • Desmosomes are adhesive junctions that are essential for epithelial barrier function. Here, Kurinna et al. identify a role for the transcription factor Nrf2 in regulating the expression of micro-RNA genes that control the integrity of desmosomes, through modulating the expression of desmocollin-2.

    • Svitlana Kurinna
    • Matthias Schäfer
    • Sabine Werner
    Research
    Nature Communications
    Volume: 5, P: 1-13