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Showing 1–3 of 3 results
Advanced filters: Author: Emmanuelle Guillou Clear advanced filters

  • Impaired adipocyte insulin signalling characterizes insulin resistance. Here the authors show that the hormone-sensitive lipase can sequester the glucose-responsive transcription factor ChREBP in the cytoplasm, which prevents transcription of its target ELOVL6, resulting in reduced insulin signalling.

    • Pauline Morigny
    • Marianne Houssier
    • Dominique Langin
    Research
    Nature Metabolism
    Volume: 1, P: 133-146

  • DNA double-strand breaks (DSBs) may be repaired either by homologous recombination (HR) or nonhomologous end joining (NHEJ) pathways. A new high-resolution mapping study of DSBs in human cells shows that trimethylated histone H3 K36, a marker of active chromatin, targets RAD51 to DSBs within transcribed regions to promote preferential HR-mediated repair at transcriptionally active loci.

    • François Aymard
    • Beatrix Bugler
    • Gaëlle Legube
    Research
    Nature Structural & Molecular Biology
    Volume: 21, P: 366-374