Lower levels of ω–3 fatty acid–derived resolution mediators have been linked to insulin resistance in obese mice. André Marette and his colleagues now show that treatment of obese mice with a resolution mediator (protectin DX (PDX)) results in IL-6 release from muscle and subsequent improvement in insulin sensitivity. PDX may represent a new class of antidiabetes medication.
- Phillip J White
- Philippe St-Pierre
- André Marette
