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Showing 1–7 of 7 results
Advanced filters: Author: Enfu Hui Clear advanced filters

  • Synaptotagmin-1 aggregates membranes in response to Ca2+. Using a variety of approaches, it was discovered that synaptotagmin-mediated membrane aggregation occurs through trans interactions between synaptotagmin molecules bound to different membranes. Synaptotagmin-regulated, SNARE-catalyzed fusion further requires synaptotagmin to drive the assembly of nonfusogenic syntaxin and SNAP25 into fusion-competent t-SNARE heterodimers.

    • Enfu Hui
    • Jon D Gaffaney
    • Edwin R Chapman
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 813-821

  • Different kinases and phosphatases control the triggering of T-cell receptors. This signaling network is now reconstituted in vitro with CD3ζ, Lck, CD45, Csk and liposomes. Rigorous quantitative analyses reveal how the system is maintained in a quiescent state and how the kinase-phosphatase balance can be modulated by different events to allow activation in an ultrasensitive manner.

    • Enfu Hui
    • Ronald D Vale
    Research
    Nature Structural & Molecular Biology
    Volume: 21, P: 133-142

  • Synaptotagmin is generally accepted as being the calcium sensor in SNARE-mediated calcium-triggered synaptic vesicle fusion. New data now indicate that synaptotagmin may negatively regulate the SNARE complex in the absence of calcium, and that interactions with target SNARE proteins may help steer synaptotagmin to the target membrane in a calcium-independent manner.

    • Michael C Chicka
    • Enfu Hui
    • Edwin R Chapman
    Research
    Nature Structural & Molecular Biology
    Volume: 15, P: 827-835