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Advanced filters: Author: Enrique Garcia-Rivera Clear advanced filters

Highly specific intracellular ubiquitination of a small molecule

Li et al. discovered that the cytotoxic synthetic small molecule BRD1732 is directly ubiquitinated in cells. Ubiquitination of BRD1732 is E3 ligase dependent and leads to inhibition of proteasomal degradation.

Weicheng Li
Enrique M. Garcia-Rivera
Jonathan M. L. Ostrem
ResearchOpen Access21 Aug 2025
Nature Chemical Biology

P: 1-9
Author Correction: Pan-cancer multi-omic model of LINE-1 activity reveals locus heterogeneity of retrotransposition efficiency

Alexander Solovyov
Julie M. Behr
Benjamin D. Greenbaum
Amendments and CorrectionsOpen Access24 Mar 2025
Nature Communications

Volume: 16, P: 1
Pan-cancer multi-omic model of LINE-1 activity reveals locus heterogeneity of retrotransposition efficiency

LINE-1 activity was quantified in a large, pan-cancer dataset, finding locus-specific heterogeneity and new associations using a computational pipeline. A mathematical mediation model of p53 and L1 interactions was inferred. Somatic retrotransposition was seen in Li-Fraumeni Syndrome with heritable TP53 mutations.

Alexander Solovyov
Julie M. Behr
Benjamin D. Greenbaum
ResearchOpen Access28 Feb 2025
Nature Communications

Volume: 16, P: 1-18

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