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Showing 1–3 of 3 results
Advanced filters: Author: Enxuan Jing Clear advanced filters

  • People with the metabolic syndrome often develop gallstones. Why these two disorders are linked has not been not clear, but now Kahn and his colleagues have shown that lack of insulin signaling in the liver leads to dysregulation of genes that control the transport and synthesis of bile acids, thus altering the proper profile of bile salts and resulting in the formation of gallstones.

    • Sudha B Biddinger
    • Joel T Haas
    • C Ronald Kahn
    Research
    Nature Medicine
    Volume: 14, P: 778-782

  • During fasting SIRT3 is induced in liver and brown adipose tissue. One of SIRT3's substrates is shown to be long–chain acyl co-enzyme A dehydrogenase (LCAD). Without SIRT3 LCAD becomes hyperacetylated, which diminishes its activity, and reduces fatty acid oxidation. Mice without SIRT3 have all the hallmarks of fatty acid oxidation disorders during fasting, including reduced ATP levels and intolerance to cold. Thus, acetylation is a novel regulatory mechanism for fatty acid oxidation.

    • Matthew D. Hirschey
    • Tadahiro Shimazu
    • Eric Verdin
    Research
    Nature
    Volume: 464, P: 121-125