The basic axonal wiring of the vertebrate nervous system is set up during embryonic development, and during this process axons gain or lose sensitivity to guidance cues. Here the authors show that in proprioceptive axons, two members of the ADAM metalloproteinase family promote loss of responsiveness to Sema3A, via cleavage of its receptor Neuropilin-1.
- Erez Romi
- Irena Gokhman
- Avraham Yaron
