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Showing 1–6 of 6 results
Advanced filters: Author: Eric D Cocker Clear advanced filters

  • The Hippo pathway regulates the differentiation of stem and progenitor cells, but it is unclear how it acts in liver development. Here, the authors knockout Hippo pathway components Lats1 and 2in the liver, causing suppression of hepatocyte differentiation but promoting biliary cell differentiation.

    • Da-Hye Lee
    • Jae Oh Park
    • Dae-Sik Lim
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14

  • A miniature epifluorescence microscope that can be carried by a freely-moving adult mouse allows cellular-level imaging of neuronal spiking or measurement of microcirculation during normal behavioral activities.

    • Benjamin A Flusberg
    • Axel Nimmerjahn
    • Mark J Schnitzer
    Research
    Nature Methods
    Volume: 5, P: 935-938

  • An integrated, miniature (1.9 g) fluorescence microscope containing light source, optics and sensor allows high-speed, wide field of view imaging of calcium spiking in hundreds of neurons in freely moving mice. The mass-producible portable microscope is also useful for a variety of fluorescence assays for which size, cost and portability can be concerns.

    • Kunal K Ghosh
    • Laurie D Burns
    • Mark J Schnitzer
    Research
    Nature Methods
    Volume: 8, P: 871-878

  • The authors use Ca2+ imaging in freely behaving mice to look at the long-term dynamics of CA1 hippocampal place codes. They find that, in a familiar environment, there is substantial change in the population of place-coding cells over time, but the ensembles of these cells are sufficiently stable to preserve an accurate spatial representation across weeks.

    • Yaniv Ziv
    • Laurie D Burns
    • Mark J Schnitzer
    Research
    Nature Neuroscience
    Volume: 16, P: 264-266