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Modern Pathology (24)
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Showing 1–50 of 67 results

Advanced filters: Author: Eric D Hsi Clear advanced filters

Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits

There is strong genetic evidence for cigarette smoking behaviors, yet little is known on nicotine dependence (ND). Here, the authors perform a genome-wide association study on ND in 58,000 smokers, identifying five genome-wide significant loci.

Bryan C. Quach
Michael J. Bray
Dana B. Hancock
ResearchOpen Access03 Nov 2020
Nature Communications

Volume: 11, P: 1-13
Hyperspectral evaluation of hepatic oxygenation in a model of total vs. arterial liver ischaemia

Eric Felli
Mahdi Al-Taher
Michele Diana
ResearchOpen Access22 Sept 2020
Scientific Reports

Volume: 10, P: 1-10
Visualisation and quantification of the effects of surgical humidification on intestinal perfusion and viability in a porcine model

Mahdi Al-Taher
Eric Felli
Michele Diana
ResearchOpen Access14 Aug 2025
Scientific Reports

Volume: 15, P: 1-11
Intrathymic signalling in immature CD4⁺ CD8⁺ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain

Toshinori Nakayama
Alfred Singer
Lawrence E. Samelson
Research19 Oct 1989
Nature

Volume: 341, P: 651-654
Ecology and genomics of an important crop wild relative as a prelude to agricultural innovation

Domestication reduces genetic diversity and constrains crop improvement. Here the authors identify factors that shaped species diversity in the wild progenitors of chickpea, and produce wild introgression populations that increase diversity for breeding by ~100-fold, including traits of agronomic relevance.

Eric J.B. von Wettberg
Peter L. Chang
Douglas R. Cook
ResearchOpen Access13 Feb 2018
Nature Communications

Volume: 9, P: 1-13
Hyperspectral images of grapevine leaves including healthy leaves and leaves with biotic and abiotic symptoms

Maxime Ryckewaert
Daphné Héran
Ryad Bendoula
ResearchOpen Access26 Oct 2023
Scientific Data

Volume: 10, P: 1-9
Triamidoamine uranium(IV)–arsenic complexes containing one-, two- and threefold U–As bonding interactions

The nature of actinide–ligand bonding is attracting attention, in particular in the context of nuclear waste separations. Structurally authenticated one-, two- and threefold uranium–arsenic bonding interactions are now reported. Computational analysis suggests the presence of polarized σ², σ²π², and σ²π⁴ in the arsenide, terminal arsinidene, and arsenido complexes, respectively.

Benedict M. Gardner
Gábor Balázs
Stephen T. Liddle
Research15 Jun 2015
Nature Chemistry

Volume: 7, P: 582-590
Conjunctival tick bite

Kun Hsi Chu
Alexander Kwok
Abdelrahman M. Elhusseiny
Research01 Apr 2025
Eye

P: 1-2
In vivo base editing extends lifespan of a humanized mouse model of prion disease

An in vivo base editing approach targeting the PRNP gene led to a 52% increase in the lifespan of mouse models inoculated with the most common sporadic and genetic types of human pathogenic prion isolate.

Meirui An
Jessie R. Davis
David R. Liu
ResearchOpen Access14 Jan 2025
Nature Medicine

Volume: 31, P: 1319-1328
Disruption of Autolysis in Bacillus subtilis using TiO₂ Nanoparticles

Eric McGivney
Linchen Han
Kelvin B. Gregory
ResearchOpen Access17 Mar 2017
Scientific Reports

Volume: 7, P: 1-11
Uneven increases in racial diversity of US geoscience undergraduates

Over the past 20 years, the proportion of US geoscience undergraduate degree recipients from marginalized racial groups has increased about threefold, more than for graduate degrees. Much of this progress currently is concentrated at relatively few universities.

Rachel J. Beane
Eric M. D. Baer
Lisa D. White
Comments & OpinionOpen Access15 Jun 2021
Communications Earth & Environment

Volume: 2, P: 1-4
A Therapeutically Relevant Difference in Leukemia and Normal Stem Cell Self Renewal

Soledad Negrotto
Zhenbo Hu
Yogen Saunthararajah
ResearchOpen Access09 Apr 2009
Nature Precedings

P: 1
An integrated map of structural variation in 2,504 human genomes

The Structural Variation Analysis Group of The 1000 Genomes Project reports an integrated structural variation map based on discovery and genotyping of eight major structural variation classes in 2,504 unrelated individuals from across 26 populations; structural variation is compared within and between populations and its functional impact is quantified.

Peter H. Sudmant
Tobias Rausch
Jan O. Korbel
ResearchOpen Access30 Sept 2015
Nature

Volume: 526, P: 75-81
SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells

SLC25A39 and its paralogue SLC25A40 have redundant roles in the import of glutathione into mitochondria of mammalian cells.

Ying Wang
Frederick S. Yen
Kıvanç Birsoy
Research27 Oct 2021
Nature

Volume: 599, P: 136-140
The glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells

Lysosomal replacement enzymes are taken up by cell surface receptors that recognize glycans, the effects of different glycan features are unknown. Here the authors present a gene engineering screen in CHO cells that allows custom N-glycan-decorated enzymes with improved circulation time and organ distribution.

Weihua Tian
Zilu Ye
Zhang Yang
ResearchOpen Access30 Apr 2019
Nature Communications

Volume: 10, P: 1-13
Prognostic gene expression and microRNA profiling signatures and genetic alterations in primary testicular diffuse large B-cell lymphoma

Wenyu Shi
Zijun Y. Xu-Monette
Ken H. Young
ResearchOpen Access17 Jul 2025
Blood Cancer Journal

Volume: 15, P: 1-12
Tissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant

TP53 mutations can cause increased risk for cancers. Here, the authors show a noncoding polymorphism in TP53 increases risk of some cancers but delays onset of others, and in a mouse model show this is via alteration of microRNA targeting sites that differ in impact depending on the tissue.

Qipan Deng
Hui Hu
Yong Li
ResearchOpen Access07 Nov 2019
Nature Communications

Volume: 10, P: 1-13
Modified apoptotic molecule (BID) reduces hepatitis C virus infection in mice with chimeric human livers

Eric C. Hsu
Belinda Hsi
Christopher D. Richardson
Research21 Apr 2003
Nature Biotechnology

Volume: 21, P: 519-525
Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group

Sarah M. C. Colbert
Eric T. Monson
Lea Zillich
ReviewsOpen Access25 Sept 2025
Molecular Psychiatry

P: 1-11
A reevaluation of erythroid predominance in Acute Myeloid Leukemia using the updated WHO 2016 Criteria

Elizabeth Margolskee
Geoff Mikita
Attilio Orazi
Research05 Feb 2018
Modern Pathology

Volume: 31, P: 873-880
Assembly and diploid architecture of an individual human genome via single-molecule technologies

A combination of single-molecule long-read sequencing, single-molecule genome mapping and short-read sequencing provides reference-quality de novo assemblies and also shows improved phasing and variant detection over short-read assemblies when mapping to a reference genome.

Matthew Pendleton
Robert Sebra
Ali Bashir
Research29 Jun 2015
Nature Methods

Volume: 12, P: 780-786
Expression of SHP-1 Phosphatase Indicates Post-Germinal Center Cell Derivation of B-Cell Posttransplant Lymphoproliferative Disorders

Michele Paessler
Plamen Kossev
Mariusz A Wasik
Research01 Nov 2002
Laboratory Investigation

Volume: 82, P: 1599-1606
Electronic Metamaterials with Tunable Second-order Optical Nonlinearities

Hung-Hsi Lin
Felipe Vallini
Yeshaiahu Fainman
ResearchOpen Access30 Aug 2017
Scientific Reports

Volume: 7, P: 1-7
In situ assembly of enzyme inhibitors using extended tethering

Daniel A. Erlanson
Joni W. Lam
Tom O'Brien
Research03 Feb 2003
Nature Biotechnology

Volume: 21, P: 308-314
IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes

Most of the more than 200 known genetic risk loci for inflammatory bowel disease (IBD) reside in regulatory regions. Here, the authors provide eQTL datasets for six circulating immune cell types and ileal, colonic and rectal biopsies to map regulatory modules and identify potential causative genes for IBD.

Yukihide Momozawa
Julia Dmitrieva
Michel Georges
ResearchOpen Access21 Jun 2018
Nature Communications

Volume: 9, P: 1-18
36-month durability of ultrasound renal denervation for hypertension resistant to combination therapy in RADIANCE-HTN TRIO

Michael J. Bloch
Ajay J. Kirtane
Patric Kröpil
ResearchOpen Access27 Sept 2024
Hypertension Research

Volume: 47, P: 3467-3472
Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond

Nathan Gaddis
Ravi Mathur
Eric Otto Johnson
ResearchOpen Access07 Oct 2022
Scientific Reports

Volume: 12, P: 1-16
The genetic landscape of mutations in Burkitt lymphoma

Sandeep Dave and colleagues report exome sequencing of 59 Burkitt lymphomas. They report recurrent mutations in many genes, including ID3, MYC, GNA13, RET, PIK3R1, NOTCH1 and the SWI/SNF genes ARID1A and SMARCA4.

Cassandra Love
Zhen Sun
Sandeep S Dave
Research11 Nov 2012
Nature Genetics

Volume: 44, P: 1321-1325
The GAGOme: a cell-based library of displayed glycosaminoglycans

A CHO cell library displaying a near-complete repertoire of glycosaminoglycan (GAG) modifications provides a resource for cell-based binding assays, recombinant proteoglycan expression, and assembly of GAG glycan microarrays.

Yen-Hsi Chen
Yoshiki Narimatsu
Zhang Yang
Research13 Aug 2018
Nature Methods

Volume: 15, P: 881-888
High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis

John Rioux, Andre Franke, Tom Karlsen and colleagues perform a fine-mapping study of the HLA region in Crohn's disease and ulcerative colitis. They identify a primary role for HLA-DRB1*01:03 in both diseases and find evidence of heterozygous advantage in protection against ulcerative colitis.

Philippe Goyette
Gabrielle Boucher
John D Rioux
Research05 Jan 2015
Nature Genetics

Volume: 47, P: 172-179
Determining clinical course of diffuse large B-cell lymphoma using targeted transcriptome and machine learning algorithms

Maher Albitar
Hong Zhang
Ken H. Young
ResearchOpen Access01 Feb 2022
Blood Cancer Journal

Volume: 12, P: 1-9
Follicular Lymphoma with Marginal Zone Differentiation: Microdissection Demonstrates the t(14;18) in Both the Follicular and Marginal Zone Components

Subramanian Yegappan
Bertram Schnitzer
Eric D Hsi
Research01 Mar 2001
Modern Pathology

Volume: 14, P: 191-196
Association of polygenic score for major depression with response to lithium in patients with bipolar disorder

Azmeraw T. Amare
Klaus Oliver Schubert
Bernhard T. Baune
Research16 Mar 2020
Molecular Psychiatry

Volume: 26, P: 2457-2470
Development of a modeling approach to estimate indoor-to-outdoor sulfur ratios and predict indoor PM_2.5 and black carbon concentrations for Eastern Massachusetts households

Chia Hsi Tang
Eric Garshick
Petros Koutrakis
ResearchOpen Access18 Oct 2017
Journal of Exposure Science & Environmental Epidemiology

Volume: 28, P: 125-130
Specificity of IRF4 translocations for primary cutaneous anaplastic large cell lymphoma: a multicenter study of 204 skin biopsies

David A Wada
Mark E Law
Andrew L Feldman
Research17 Dec 2010
Modern Pathology

Volume: 24, P: 596-605
Immunohistochemical Analysis of CD30-Positive Lymphoproliferative Disorders for Expression of CD95 and CD95L

Jessica E Sigel
Eric D Hsi
Research01 Apr 2000
Modern Pathology

Volume: 13, P: 446-451
Human herpesvirus 8-negative effusion-based large B-cell lymphoma: a distinct entity with unique clinicopathologic characteristics

Savanah D. Gisriel
Ji Yuan
Zenggang Pan
Research13 May 2022
Modern Pathology

Volume: 35, P: 1411-1422
Immunohistochemical detection of human herpes virus-8 latent nuclear antigen-1 is useful in the diagnosis of Kaposi sarcoma

Rajiv M Patel
John R Goldblum
Eric D Hsi
Research27 Feb 2004
Modern Pathology

Volume: 17, P: 456-460
Resistance to BTK inhibition by ibrutinib can be overcome by preventing FOXO3a nuclear export and PI3K/AKT activation in B-cell lymphoid malignancies

Isha Kapoor
Yue Li
Alexandru Almasan
ResearchOpen Access04 Dec 2019
Cell Death & Disease

Volume: 10, P: 1-12
Hepatitis C virus positive diffuse large B-cell lymphomas have distinct molecular features and lack BCL2 translocations

Carlo Visco
Jinfen Wang
Ken H Young
ResearchOpen Access26 Sept 2017
British Journal of Cancer

Volume: 117, P: 1685-1688
Expression of HGAL in primary cutaneous large B-cell lymphomas: evidence for germinal center derivation of primary cutaneous follicular lymphoma

Xiuyan Xie
Uma Sundram
Eric D Hsi
Research08 Feb 2008
Modern Pathology

Volume: 21, P: 653-659
Myeloid/lymphoid neoplasms with FLT3 rearrangement

Guilin Tang
Wayne Tam
Sa A. Wang
Research14 May 2021
Modern Pathology

Volume: 34, P: 1673-1685
A novel CDK9 inhibitor increases the efficacy of venetoclax (ABT-199) in multiple models of hematologic malignancies

Darren C. Phillips
Sha Jin
Andrew J. Souers
ResearchOpen Access11 Dec 2019
Leukemia

Volume: 34, P: 1646-1657
Myelodysplastic/myeloproliferative neoplasms-unclassifiable with isolated isochromosome 17q represents a distinct clinico-biologic subset: a multi-institutional collaborative study from the Bone Marrow Pathology Group

Rashmi Kanagal-Shamanna
Attilio Orazi
Carlos Bueso-Ramos
Research13 Nov 2021
Modern Pathology

Volume: 35, P: 470-479
CD6-targeted antibody-drug conjugate as a new therapeutic agent for T cell lymphoma

Neetha Parameswaran
Liping Luo
Feng Lin
Research12 Aug 2023
Leukemia

Volume: 37, P: 2050-2057
Decitabine- and 5-azacytidine resistance emerges from adaptive responses of the pyrimidine metabolism network

Xiaorong Gu
Rita Tohme
Yogen Saunthararajah
ResearchOpen Access07 Aug 2020
Leukemia

Volume: 35, P: 1023-1036
PD-1/PD-L1 expression and interaction by automated quantitative immunofluorescent analysis show adverse prognostic impact in patients with diffuse large B-cell lymphoma having T-cell infiltration: a study from the International DLBCL Consortium Program

Ling Li
Ruifang Sun
Ken H. Young
Research21 Jan 2019
Modern Pathology

Volume: 32, P: 741-754
Correction to: Myelodysplastic/myeloproliferative neoplasms-unclassifiable with isolated isochromosome 17q represents a distinct clinico-biologic subset: a multi-institutional collaborative study from the Bone Marrow Pathology Group

Rashmi Kanagal-Shamanna
Attilio Orazi
Carlos Bueso-Ramos
Amendments and Corrections13 Dec 2021
Modern Pathology

Volume: 35, P: 705
Hematopoietic neoplasms with 9p24/JAK2 rearrangement: a multicenter study

Guilin Tang
John Kennedy Sydney Sir Philip
Sa A. Wang
Research06 Nov 2018
Modern Pathology

Volume: 32, P: 490-498
Genomic and epidemiological characterisation of a dengue virus outbreak among blood donors in Brazil

Nuno R. Faria
Antonio Charlys da Costa
Simone A. Glynn
ResearchOpen Access09 Nov 2017
Scientific Reports

Volume: 7, P: 1-12

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