Basophils initiate T helper type 2 responses after exposure to allergens and IgE immune complexes. Juan Rivera and his colleagues find that elevated amounts of IgE in Lyn−/− mice drive basophil activation, secretion of T helper type 2 cytokines and production of autoantibodies, leading to a lupus-like phenotype in mice and to glomerulonephritis. Depletion of basophils or deficiencies in IgE or interleukin-4 are sufficient to reduce autoantibody production and prevent kidney damage. Data from subjects with SLE suggest that increased IgE levels and activated basophils may contribute to disease.
- Nicolas Charles
- Donna Hardwick
- Juan Rivera
