Nature Search

DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans

The C. elegans PIWI protein PRG-1 resides in the membraneless organelle P granule. Here, the authors identify the constitutive P granule protein DEPS-1 as an interactor of PRG-1 and show its function in piRNA-dependent silencing. DEPS-1 and PRG-1 form elongated condensates in vivo.

Kin Man Suen
Fabian Braukmann
Eric Alexander Miska
ResearchOpen Access25 Aug 2020
Nature Communications

Volume: 11, P: 1-13
Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation in mice

SUMOylation is a mechanism of posttranslational modification involved in eukaryotic cell homeostasis. Here the authors report that mice unable to control SUMOylation in the adrenal cortex develop a selective defect in glucocorticoid production due to disrupted differentiation of cells involved in steroid hormone synthesis.

Damien Dufour
Typhanie Dumontet
Antoine Martinez
ResearchOpen Access21 Dec 2022
Nature Communications

Volume: 13, P: 1-18
Murine neuroblastoma cured in vivo by an antibody-dependent cellular cytotoxicity reaction

JOHN E. BYFIELD
RAQUEL ZERUBAVEL
ERIC W. FONKALSRUD
Research23 Dec 1976
Nature

Volume: 264, P: 783-785
Mercury fluxes from hydrothermal venting at mid-ocean ridges constrained by measurements

Hydrothermal venting makes limited contribution to the inventory of oceanic mercury compared with anthropogenic inputs, according to measurements at mid-ocean ridges.

Natalia Torres-Rodriguez
Jingjing Yuan
Lars-Eric Heimbürger-Boavida
ResearchOpen Access12 Dec 2023
Nature Geoscience

Volume: 17, P: 51-57
Repeated blood–brain barrier opening with a nine-emitter implantable ultrasound device in combination with carboplatin in recurrent glioblastoma: a phase I/II clinical trial

Recent work indicates that drug delivery to the brain can be improved through disruption of the blood brain barrier using low intensity pulsed ultrasound. Here, the authors report a phase I/II clinical trial investigating the combination of a nine-emitter implantable ultrasound device and carboplatin in patients with recurrent glioblastoma.

Alexandre Carpentier
Roger Stupp
Ahmed Idbaih
ResearchOpen Access23 Feb 2024
Nature Communications

Volume: 15, P: 1-12
Mercury stable isotopes constrain atmospheric sources to the ocean

Mercury deposition pathways from the atmosphere to the ocean remain uncertain, but mercury stable isotope measurements from the Atlantic and Mediterranean show that ocean uptake of gaseous elemental mercury is more important than previously thought.

Martin Jiskra
Lars-Eric Heimbürger-Boavida
Jeroen E. Sonke
Research29 Sept 2021
Nature

Volume: 597, P: 678-682
Arctic Ocean’s wintertime mercury concentrations limited by seasonal loss on the shelf

The mercury concentration in the Arctic Ocean is lower and less variable in winter than in summer due to seasonal loss of inorganic mercury on the shelf, according to mercury measurements along a gradient in the northern Barents Sea.

Stephen G. Kohler
Lars-Eric Heimbürger-Boavida
Murat V. Ardelan
Research18 Jul 2022
Nature Geoscience

Volume: 15, P: 621-626
A high-risk retinoblastoma subtype with stemness features, dedifferentiated cone states and neuronal/ganglion cell gene expression

Retinoblastoma is the most frequent intraocular paediatric malignancy whose molecular basis remains poorly understood. Here, the authors perform multi-omic analysis and identify two subtypes; one in a cone differentiated state and one more aggressive showing cone dedifferentiation and expressing neuronal markers.

Jing Liu
Daniela Ottaviani
François Radvanyi
ResearchOpen Access22 Sept 2021
Nature Communications

Volume: 12, P: 1-20
Active thrombin produced by the intestinal epithelium controls mucosal biofilms

The roles played by thrombin in the human intestinal mucosa are unclear. Here, the authors show that the commensal microbiota modulates epithelial production of active thrombin, which controls biofilm growth and contributes to protection of the mucosa from bacterial invasion.

Jean-Paul Motta
Alexandre Denadai-Souza
Nathalie Vergnolle
ResearchOpen Access19 Jul 2019
Nature Communications

Volume: 10, P: 1-12
Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter- and intracontinental transmission events

Vanessa Wong and colleagues report whole-genome sequencing of 1,832 Salmonella enterica serovar Typhi isolates from 63 endemic countries. They identify mutations that define the multidrug resistant (MDR) H58 lineage and report numerous inter- and intracontinental transmissions of this lineage as well as an ongoing MDR typhoid epidemic in Africa.

Vanessa K Wong
Stephen Baker
Gordon Dougan
Research11 May 2015
Nature Genetics

Volume: 47, P: 632-639
A randomized trial to determine the minimum effective lidocaine volume for median nerve block using hydrodissection

Eric Dufour
Souhail Jaziri
Marc Fischler
ResearchOpen Access07 Jan 2022
Scientific Reports

Volume: 12, P: 1-8
Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca²⁺ channel–vesicle coupling

Coupling distances between synaptic vesicles and Ca²⁺ channels determine the efficacy of neurotransmission. Böhme et al. find that presynaptic scaffold complexes spatiotemporally control Unc13 isoforms to establish two independent release pathways at subsynaptic active zones: Unc13B defines nascent, loosely coupled synapses whereas Unc13A facilitates release at mature synapses by tight coupling between Ca²⁺ channels and synaptic vesicles.

Mathias A Böhme
Christina Beis
Stephan J Sigrist
Research15 Aug 2016
Nature Neuroscience

Volume: 19, P: 1311-1320
An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD)

The LITMUS consortium provides a resource of rodent MASLD models benchmarked against metabolic, histologic and transcriptomic features that are relevant for human MASLD. The work is useful for selecting relevant rodent models for studying this common disease.

Michele Vacca
Ioannis Kamzolas
Antonio Vidal-Puig
ResearchOpen Access12 Jun 2024
Nature Metabolism

Volume: 6, P: 1178-1196
An extended genotyping framework for Salmonella enterica serovar Typhi, the cause of human typhoid

Typhoid fever is caused by Salmonella enterica serovar Typhi (S. Typhi). This study examines ∼2,000 clinical isolates of S. Typhi to show highly structured/geographically restricted genomes except rapidly disseminating H58 subclade, and design a genotyping framework for tracking the disease.

Vanessa K. Wong
Stephen Baker
Ben Amos
ResearchOpen Access05 Oct 2016
Nature Communications

Volume: 7, P: 1-11
High permittivity processed SrTiO₃ for metamaterials applications at terahertz frequencies

Cyrielle Dupas
Sophie Guillemet-Fritsch
Éric Akmansoy
ResearchOpen Access15 Oct 2018
Scientific Reports

Volume: 8, P: 1-8
Inference of interactions in cyanobacterial–heterotrophic co-cultures via transcriptome sequencing

Alexander S Beliaev
Margie F Romine
Allan Konopka
Research29 Apr 2014
The ISME Journal

Volume: 8, P: 2243-2255
Palaeoenvironments and hominin evolutionary dynamics in southeast Asia

Anne-Marie Bacon
Nicolas Bourgon
Jean-Jacques Hublin
ResearchOpen Access27 Sept 2023
Scientific Reports

Volume: 13, P: 1-13
Author Correction: A joint international consensus statement for measuring quality of survival for patients with childhood cancer

Rebecca J. van Kalsbeek
Melissa M. Hudson
Lisa Zwiers
Amendments and Corrections22 May 2024
Nature Medicine

Volume: 30, P: 2091
Surveillance after childhood cancer: are survivors with an increased risk for cardiomyopathy regularly followed-up?

Nicolas Bougas
Rodrigue S. Allodji
Agnès Dumas
Research21 Aug 2023
British Journal of Cancer

Volume: 129, P: 1298-1305
Author Correction: A joint international consensus statement for measuring quality of survival for patients with childhood cancer

Rebecca J. van Kalsbeek
Melissa M. Hudson
Lisa Zwiers
Amendments and Corrections14 Nov 2023
Nature Medicine

Volume: 30, P: 603
Author Correction: A joint international consensus statement for measuring quality of survival for patients with childhood cancer

Rebecca J. van Kalsbeek
Melissa M. Hudson
Lisa Zwiers
Amendments and Corrections13 Dec 2023
Nature Medicine

Volume: 30, P: 605
A multi-proxy approach to exploring Homo sapiens’ arrival, environments and adaptations in Southeast Asia

Anne-Marie Bacon
Nicolas Bourgon
Élise Dufour
ResearchOpen Access26 Oct 2021
Scientific Reports

Volume: 11, P: 1-14
A joint international consensus statement for measuring quality of survival for patients with childhood cancer

The International Childhood Cancer Outcome Project group, involving survivors and other relevant stakeholders, develop a set of core outcomes to measure the quality of care for 17 types of childhood cancers.

Rebecca J. van Kalsbeek
Melissa M. Hudson
Lisa Zwiers
Reviews15 Jun 2023
Nature Medicine

Volume: 29, P: 1340-1348
Extracellular DNA release, quorum sensing, and PrrF1/F2 small RNAs are key players in Pseudomonas aeruginosa tobramycin-enhanced biofilm formation

Ali Tahrioui
Rachel Duchesne
Sylvie Chevalier
ResearchOpen Access23 May 2019
npj Biofilms and Microbiomes

Volume: 5, P: 1-11
Bromodomain factors of BET family are new essential actors of pericentric heterochromatin transcriptional activation in response to heat shock

Edwige Col
Neda Hoghoughi
Claire Vourc’h
ResearchOpen Access14 Jul 2017
Scientific Reports

Volume: 7, P: 1-12
Neurophysiological responses to unpleasant stimuli (acute electrical stimulations and emotional pictures) are increased in patients with schizophrenia

Céline Z. Duval
Yannick Goumon
Anne Giersch
ResearchOpen Access03 Mar 2016
Scientific Reports

Volume: 6, P: 1-10
Diiron centre mutations in Ciona intestinalis alternative oxidase abolish enzymatic activity and prevent rescue of cytochrome oxidase deficiency in flies

Ana Andjelković
Marcos T. Oliveira
Howard T. Jacobs
ResearchOpen Access17 Dec 2015
Scientific Reports

Volume: 5, P: 1-9
Archaea and bacteria mediate the effects of native species root loss on fungi during plant invasion

Steven D Mamet
Eric G Lamb
Steven D Siciliano
Research31 Jan 2017
The ISME Journal

Volume: 11, P: 1261-1275
A global database for metacommunity ecology, integrating species, traits, environment and space

Alienor Jeliazkov
Darko Mijatovic
Jonathan M. Chase
ResearchOpen Access08 Jan 2020
Scientific Data

Volume: 7, P: 1-15
Oral capecitabine vs intravenous 5-fluorouracil and leucovorin: integrated efficacy data and novel analyses from two large, randomised, phase III trials

E Van Cutsem
P M Hoff
R L Schilsky
ResearchOpen Access24 Feb 2004
British Journal of Cancer

Volume: 90, P: 1190-1197
Lake microbial communities are resilient after a whole-ecosystem disturbance

Ashley Shade
Jordan S Read
Katherine D McMahon
ResearchOpen Access28 Jun 2012
The ISME Journal

Volume: 6, P: 2153-2167

Search

DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans

Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation in mice

Murine neuroblastoma cured in vivo by an antibody-dependent cellular cytotoxicity reaction

Mercury fluxes from hydrothermal venting at mid-ocean ridges constrained by measurements

Repeated blood–brain barrier opening with a nine-emitter implantable ultrasound device in combination with carboplatin in recurrent glioblastoma: a phase I/II clinical trial

Mercury stable isotopes constrain atmospheric sources to the ocean

Arctic Ocean’s wintertime mercury concentrations limited by seasonal loss on the shelf

A high-risk retinoblastoma subtype with stemness features, dedifferentiated cone states and neuronal/ganglion cell gene expression

Active thrombin produced by the intestinal epithelium controls mucosal biofilms

Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter- and intracontinental transmission events

A randomized trial to determine the minimum effective lidocaine volume for median nerve block using hydrodissection

Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca²⁺ channel–vesicle coupling

An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD)

An extended genotyping framework for Salmonella enterica serovar Typhi, the cause of human typhoid

High permittivity processed SrTiO₃ for metamaterials applications at terahertz frequencies

Inference of interactions in cyanobacterial–heterotrophic co-cultures via transcriptome sequencing

Palaeoenvironments and hominin evolutionary dynamics in southeast Asia

Author Correction: A joint international consensus statement for measuring quality of survival for patients with childhood cancer

Surveillance after childhood cancer: are survivors with an increased risk for cardiomyopathy regularly followed-up?

Author Correction: A joint international consensus statement for measuring quality of survival for patients with childhood cancer

Author Correction: A joint international consensus statement for measuring quality of survival for patients with childhood cancer

A multi-proxy approach to exploring Homo sapiens’ arrival, environments and adaptations in Southeast Asia

A joint international consensus statement for measuring quality of survival for patients with childhood cancer

Extracellular DNA release, quorum sensing, and PrrF1/F2 small RNAs are key players in Pseudomonas aeruginosa tobramycin-enhanced biofilm formation

Bromodomain factors of BET family are new essential actors of pericentric heterochromatin transcriptional activation in response to heat shock

Neurophysiological responses to unpleasant stimuli (acute electrical stimulations and emotional pictures) are increased in patients with schizophrenia

Diiron centre mutations in Ciona intestinalis alternative oxidase abolish enzymatic activity and prevent rescue of cytochrome oxidase deficiency in flies

Archaea and bacteria mediate the effects of native species root loss on fungi during plant invasion

A global database for metacommunity ecology, integrating species, traits, environment and space

Oral capecitabine vs intravenous 5-fluorouracil and leucovorin: integrated efficacy data and novel analyses from two large, randomised, phase III trials

Lake microbial communities are resilient after a whole-ecosystem disturbance

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