Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–5 of 5 results
Advanced filters: Author: Eric J Montemayor Clear advanced filters

  • Here, the structure of poly(UG) RNA reveals an unusual left-handed quadruplex, or ‘pUG fold’. The pUG fold marks RNAs as vectors for gene silencing in C. elegans by recruiting RNA-dependent RNA polymerase for siRNA synthesis.

    • Saeed Roschdi
    • Jenny Yan
    • Samuel E. Butcher
    Research
    Nature Structural & Molecular Biology
    Volume: 29, P: 1113-1121

  • The mechanism of U6 small nuclear ribonucleoprotein (snRNP) biogenesis is not well understood. Here the authors characterize the enzymatic activities and structures of yeast and human U6 RNA processing enzyme Usb1, reconstitute post-transcriptional assembly of yeast U6 snRNP in vitro, and propose a model for U6 snRNP assembly.

    • Allison L. Didychuk
    • Eric J. Montemayor
    • Samuel E. Butcher
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • The spliceosome removes introns from precursor messenger RNAs to produce mature mRNAs. Here the authors report a U6 snRNP crystal structure that provides insight on how the 3′ phosphate of U6 snRNA is recognized by the Lsm2–8 complex and how the U6 snRNP proteins sequester and protect the active site RNA until it is assembled into the spliceosome.

    • Eric J. Montemayor
    • Allison L. Didychuk
    • Samuel E. Butcher
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • During spliceosome assembly, U6 snRNA is recycled from U2 snRNA by the protein Prp24 and is paired with U4 snRNA to form a splicing-competent complex. A structure of yeast Prp24 bound to the conserved core of U6 RNA reveals a new arrangement of RNA-protein contacts that mediates these early events leading to pre-mRNA splicing.

    • Eric J Montemayor
    • Elizabeth C Curran
    • David A Brow
    Research
    Nature Structural & Molecular Biology
    Volume: 21, P: 544-551