Nature Search

CDC7 inhibition induces replication stress-mediated aneuploid cells with an inflammatory phenotype sensitizing tumors to immune checkpoint blockade

TAK-931 is a selective CDC7 inhibitor and can induce replication stress (RS)-mediated chromosomal instability with antitumoral activity. Here the authors show that TAK-931-induced RS generates aneuploid cells with an inflammatory phenotype, rendering tumors sensitive to immune-checkpoint blockade.

Tomoko Yamamori Morita
Jie Yu
Akihiro Ohashi

ResearchOpen Access18 Nov 2023

Nature Communications

Volume: 14, P: 1-21

Quick links

Search

Filter By:

CDC7 inhibition induces replication stress-mediated aneuploid cells with an inflammatory phenotype sensitizing tumors to immune checkpoint blockade

Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor

Search

Quick links