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Showing 1–5 of 5 results
Advanced filters: Author: Eric Linster Clear advanced filters

  • N-terminal acetylation is a common protein modification in eukaryotes. Here the authors show that in Arabidopsis, N-terminal acetylation is decreased by drought stress, that abundance of an N-terminal acetyltransferase is reduced by abscisic acid and that constitutive downregulation can confer drought resistance.

    • Eric Linster
    • Iwona Stephan
    • Markus Wirtz
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-13

  • Attenuating effects of the ketogenic diet on colorectal cancer (CRC) cell growth has been previously described. Here, using a mouse model of CRC with a humanized microbiome, the authors identify a shift toward gut bacterial species that produce stearic acid in ketogenic conditions, resulting in elevated levels of free stearate in the gut lumen, which they then show exhibits tumor-suppressing properties.

    • Mina Tsenkova
    • Madita Brauer
    • Elisabeth Letellier
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • N-terminal protein acetylation is required for plant viability. Here the authors show that reducing N-terminal acetylation by NatA leads to an increase in global protein turnover that is facilitated by absent masking of a novel N-degron

    • Eric Linster
    • Francy L. Forero Ruiz
    • Markus Wirtz
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • Plants lack the amino acid sensors that regulate TOR in metazoans. Here Dong et al. show that Arabidopsis GCN2 senses carbon and nitrogen availability for cysteine synthesis while sulfur limitation activates TOR via glucose metabolism, providing a mechanism whereby plants control growth according to nutrient availability.

    • Yihan Dong
    • Marleen Silbermann
    • Markus Wirtz
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10