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Showing 1–3 of 3 results
Advanced filters: Author: Eric M. Mulhall Clear advanced filters

  • The conversion of auditory and vestibular stimuli into electrical signals is initiated by force transmitted to a mechanotransduction channel through the tip link. Here authors show that a single tip-link bond is more mechanically stable relative to classic cadherins, and that the double stranded tip-link connection is stabilized by single strand rebinding facilitated by strong cis-dimerization domains.

    • Eric M. Mulhall
    • Andrew Ward
    • Wesley P. Wong
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • Mutations in PCDH15 cause deafness and blindness in Usher syndrome 1 F, but gene therapy is difficult because the PCDH15 sequence is too large for AAV vectors. Here, the authors engineered a miniPCDH15 that fits in AAV and rescues hearing in mouse Usher syndrome 1F models.

    • Maryna V. Ivanchenko
    • Daniel M. Hathaway
    • David P. Corey
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-21