Nature Search

DREDge: robust motion correction for high-density extracellular recordings across species

DREDge is a software tool for motion correction of high-density electrophysiology recordings. It can handle action potential or local field potential data and is demonstrated on a variety of acute or chronic recordings from humans, nonhuman primates and mice.

Charlie Windolf
Han Yu
Erdem Varol
Research06 Mar 2025
Nature Methods

Volume: 22, P: 788-800
Large-scale high-density brain-wide neural recording in nonhuman primates

Neuropixels 1.0 NHP is a 45-mm, high-density silicon probe capable of recording large numbers of neurons with single-neuron resolution from most areas in a macaque’s brain.

Eric M. Trautmann
Janis K. Hesse
Timothy Harris
ResearchOpen Access23 Jun 2025
Nature Neuroscience

Volume: 28, P: 1562-1575
Dendritic calcium signals in rhesus macaque motor cortex drive an optical brain-computer interface

Surface two-photon imaging of the brain cannot access somatic calcium signals of neurons from deep layers of the macaque cortex. Here, the authors present an implant and imaging system for chronic motion-stabilized two-photon imaging of dendritic calcium signals to drive an optical brain-computer interface in macaques.

Eric M. Trautmann
Daniel J. O’Shea
Krishna V. Shenoy
ResearchOpen Access17 Jun 2021
Nature Communications

Volume: 12, P: 1-20
Cortical preparatory activity indexes learned motor memories

In rhesus monkeys, learning of a motor task is accompanied by uniform changes in preparatory activity in motor cortex that are orthogonal to the force-predictive neural state subspace.

Xulu Sun
Daniel J. O’Shea
Krishna V. Shenoy
Research26 Jan 2022
Nature

Volume: 602, P: 274-279
Flexible neural control of motor units

Muscle fibers have diverse properties—for example, slow and fast twitch. Groups of fibers are activated by motoneurons. Marshall et al. found that motoneurons are used flexibly, presumably allowing us to intelligently employ fibers suited to each task.

Najja J. Marshall
Joshua I. Glaser
Mark M. Churchland
Research10 Oct 2022
Nature Neuroscience

Volume: 25, P: 1492-1504
An application-based taxonomy for brain–computer interfaces

Naming brain–computer interfaces according to their intended application will assist stakeholders in the evaluation of the benefits and risks of neurotechnologies.

Jacob T. Robinson
Sumner L. Norman
Chong Xie
Comments & Opinion23 Dec 2024
Nature Biomedical Engineering

Volume: 9, P: 789-791
Upregulation of PD-1 expression on HIV-specific CD8⁺ T cells leads to reversible immune dysfunction

Lydie Trautmann
Loury Janbazian
Rafick-Pierre Sekaly
Research20 Aug 2006
Nature Medicine

Volume: 12, P: 1198-1202
Inferring single-trial neural population dynamics using sequential auto-encoders

LFADS, a deep learning method for analyzing neural population activity, can extract neural dynamics from single-trial recordings, stitch separate datasets into a single model, and infer perturbations, for example, from behavioral choices to these dynamics.

Chethan Pandarinath
Daniel J. O’Shea
David Sussillo
Research17 Sept 2018
Nature Methods

Volume: 15, P: 805-815
SHP-1-mediated inhibitory signals promote responsiveness and anti-tumour functions of natural killer cells

The underlying molecular mechanisms that mediate natural killer (NK) cell tuning remain unclear. Here, the authors show that SHP-1 is essential for the function of MHC class I-specific inhibitory receptors and for setting the threshold of NK cell reactivity.

Charlotte Viant
Aurore Fenis
Eric Vivier
Research30 Oct 2014
Nature Communications

Volume: 5, P: 1-11
Performance of the 12-item WHODAS 2.0 in prodromal Huntington disease

Ji-In Kim
Jeffrey D Long
Ryan Wyse
ResearchOpen Access04 Mar 2015
European Journal of Human Genetics

Volume: 23, P: 1584-1587
Large-scale neural recordings with single neuron resolution using Neuropixels probes in human cortex

Neuropixels probes were used to simultaneously record from more than 200 cortical neurons in human participants during neurosurgical procedures. The approach could reveal insights underlying human cognition and pathology.

Angelique C. Paulk
Yoav Kfir
Sydney S. Cash
Research31 Jan 2022
Nature Neuroscience

Volume: 25, P: 252-263
Modified Neuropixels probes for recording human neurophysiology in the operating room

This Protocol documents the extensive preparation required to adopt Neuropixels probes for use in patients for recording spiking activity from up to hundreds of cortical neurons and associating it with local field potentials.

Brian Coughlin
William Muñoz
Angelique C. Paulk
Protocols11 Sept 2023
Nature Protocols

Volume: 18, P: 2927-2953
36-month durability of ultrasound renal denervation for hypertension resistant to combination therapy in RADIANCE-HTN TRIO

Michael J. Bloch
Ajay J. Kirtane
Patric Kröpil
ResearchOpen Access27 Sept 2024
Hypertension Research

Volume: 47, P: 3467-3472
The speed of change: towards a discontinuity theory of immunity?

Here, the authors present a new theoretical framework — the discontinuity theory — to account for how the immune system generates an appropriate immune response to any perceived disturbance. On the the basis of this theory, the authors present a mathematical model and provide examples to explain how this model can account for diverse immune responses.

Thomas Pradeu
Sébastien Jaeger
Eric Vivier
Comments & Opinion02 Sept 2013
Nature Reviews Immunology

Volume: 13, P: 764-769

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