Nature Search

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

Patricia Munroe, Christopher Newton-Cheh, Andrew Morris and colleagues perform association studies in over 340,000 individuals of European ancestry and identify 66 loci, of which 17 are novel, involved in blood pressure regulation. The risk SNPs are enriched for cis-regulatory elements, particularly in vascular endothelial cells.

Georg B Ehret
Teresa Ferreira
Patricia B Munroe
Research12 Sept 2016
Nature Genetics

Volume: 48, P: 1171-1184
Man-made lakes and sea-level rise

Eric Rodenburg
Research28 Jul 1994
Nature

Volume: 370, P: 258
Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits

Genome-wide association analysis in over one million individuals of European ancestry identifies 2,103 independent genetic signals (including 113 new loci) associated with blood pressure traits.

Jacob M. Keaton
Zoha Kamali
Helen R. Warren
ResearchOpen Access30 Apr 2024
Nature Genetics

Volume: 56, P: 778-791
T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV

David Klatzmann
Eric Champagne
Luc Montagnier
Research20 Dec 1984
Nature

Volume: 312, P: 767-768
Increased soldier production in ant colonies exposed to intraspecific competition

Luc Passera
Eric Roncin
Laurent Keller
Research15 Feb 1996
Nature

Volume: 379, P: 630-631
Defining the role of common variation in the genomic and biological architecture of adult human height

Timothy Frayling, Joel Hirschhorn, Peter Visscher and colleagues report a meta-analysis of genome-wide association studies for adult height in 253,288 individuals. They identify 697 variants in 423 loci significantly associated with adult height and find that these variants cluster in pathways involved in growth and together explain one-fifth of the heritability for this trait.

Andrew R Wood
Tonu Esko
Timothy M Frayling
Research05 Oct 2014
Nature Genetics

Volume: 46, P: 1173-1186
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

Meta-analyses in up to 1.3 million individuals identify 87 rare-variant associations with blood pressure traits. On average, rare variants exhibit effects ~8 times larger than the mean effects of common variants and implicate candidate causal genes at associated regions.

Praveen Surendran
Elena V. Feofanova
Joanna M. M. Howson
Research23 Nov 2020
Nature Genetics

Volume: 52, P: 1314-1332
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

On the electrocardiogram, the PR interval reflects conduction from the atria to ventricles and also serves as risk indicator of cardiovascular morbidity and mortality. Here, the authors perform genome-wide meta-analyses for PR interval in multiple ancestries and identify 141 previously unreported genetic loci.

Ioanna Ntalla
Lu-Chen Weng
Patricia B. Munroe
ResearchOpen Access21 May 2020
Nature Communications

Volume: 11, P: 1-12
Genetic studies of body mass index yield new insights for obesity biology

A genome-wide association study and Metabochip meta-analysis of body mass index (BMI) detects 97 BMI-associated loci, of which 56 were novel, and many loci have effects on other metabolic phenotypes; pathway analyses implicate the central nervous system in obesity susceptibility and new pathways such as those related to synaptic function, energy metabolism, lipid biology and adipogenesis.

Adam E. Locke
Bratati Kahali
Elizabeth K. Speliotes
Research11 Feb 2015
Nature

Volume: 518, P: 197-206
Inclusive fitness theory and eusociality

Patrick Abbot
Jun Abe
Andrew Zink
Research23 Mar 2011
Nature

Volume: 471, P: E1-E4
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Association analyses in over 1 million individuals identify 535 new loci influencing blood pressure traits. The results provide new insights into blood pressure regulation and highlight shared genetic architecture between blood pressure and lifestyle exposures.

Evangelos Evangelou
Helen R. Warren
Mark J. Caulfield
Research17 Sept 2018
Nature Genetics

Volume: 50, P: 1412-1425
Mediterranean diet and rheumatoid arthritis: A nine-year cohort study and systematic review with meta-analysis

Peipei Hu
Eric Kam-Pui Lee
Benjamin Hon-Kei Yip
ResearchOpen Access07 May 2025
European Journal of Clinical Nutrition

Volume: 79, P: 888-896
Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

Analysis of HbA1c and FPG levels across 117 population-based studies demonstrates regional variation in prevalence of previously undiagnosed screen-detected diabetes using one or both measures and suggests that use of elevated FPG alone could underestimate diabetes prevalence in low- and middle-income countries.

Bin Zhou
Kate E. Sheffer
Majid Ezzati
ResearchOpen Access09 Nov 2023
Nature Medicine

Volume: 29, P: 2885-2901
Short-chain ketone production by engineered polyketide synthases in Streptomyces albus

Mutating natural enzymes is effective in broadening the substrate or product range, but generally leads to reduced titers. Here the authors engineer hybrid polyketide synthases for efficient production of short-chain ketones from plant biomass hydrolysates in Streptomyces, which can increase the octane of gasoline.

Satoshi Yuzawa
Mona Mirsiaghi
Jay D. Keasling
ResearchOpen Access01 Nov 2018
Nature Communications

Volume: 9, P: 1-8
Repositioning of the global epicentre of non-optimal cholesterol

From 1980 to 2018, the levels of total and non-high-density lipoprotein cholesterol increased in low- and middle-income countries, especially in east and southeast Asia, and decreased in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe.

Cristina Taddei
Bin Zhou
Majid Ezzati
ResearchOpen Access03 Jun 2020
Nature

Volume: 582, P: 73-77
New genetic loci link adipose and insulin biology to body fat distribution

Genome-wide association meta-analyses of waist-to-hip ratio adjusted for body mass index in more than 224,000 individuals identify 49 loci, 33 of which are new and many showing significant sexual dimorphism with a stronger effect in women; pathway analyses implicate adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution.

Dmitry Shungin
Thomas W. Winkler
Karen L Mohlke
Research11 Feb 2015
Nature

Volume: 518, P: 187-196
Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals

Folkersen et al. report the first results from the SCALLOP consortium, a collaborative framework for pQTL mapping and biomarker analysis of proteins on the Olink platform. A total of 315 primary and 136 secondary pQTLs for 85 circulating cardiovascular proteins from over 30,000 individuals were identified and replicated to yield new insights for translational studies and drug development.

Lasse Folkersen
Stefan Gustafsson
Anders Mälarstig
Research16 Oct 2020
Nature Metabolism

Volume: 2, P: 1135-1148
Genetic loci associated with heart rate variability and their effects on cardiac disease risk

Heart rate variability (HRV) describes the individual variation in cardiac cycle duration and is a measure of vagal control of heart rate. Here, the authors identify seventeen single-nucleotide polymorphisms associated with HRV, lending new insight into the vagal regulation of heart rhythm.

Ilja M. Nolte
M. Loretto Munoz
Eco J. C. de Geus
ResearchOpen Access14 Jun 2017
Nature Communications

Volume: 8, P: 1-17
Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

Praveen Surendran
Elena V. Feofanova
Joanna M. M. Howson
Amendments and Corrections16 Mar 2021
Nature Genetics

Volume: 53, P: 762
Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Contrary to the view that urbanization is a major driver of the global rise in obesity, the global increase in body-mass index is shown to be mostly due to increases in the body-mass indexes of rural populations.

Honor Bixby
James Bentham
Majid Ezzati
ResearchOpen Access08 May 2019
Nature

Volume: 569, P: 260-264
Erratum: Genetic loci associated with heart rate variability and their effects on cardiac disease risk

Ilja M. Nolte
M. Loretto Munoz
Eco J. C. de Geus
Amendments and CorrectionsOpen Access02 Aug 2017
Nature Communications

Volume: 8, P: 1-2
Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Evangelos Evangelou
Helen R. Warren
Mark J. Caulfield
Amendments and Corrections14 Nov 2018
Nature Genetics

Volume: 50, P: 1755
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics

An integrated analysis of over 100 single-cell and single-nucleus transcriptomics studies illustrates severe acute respiratory syndrome coronavirus 2 viral entry gene coexpression patterns across different human tissues, and shows association of age, smoking status and sex with viral entry gene expression in respiratory cell populations.

Christoph Muus
Malte D. Luecken
Xiaohui Zhang
Research02 Mar 2021
Nature Medicine

Volume: 27, P: 546-559
Microbial production of advanced biofuels

Biofuels produced by conversion of biomass by engineered microorganisms have the potential to replace fossil fuels and reduce carbon emissions. In this Review, Keasling and colleagues discuss engineering of metabolic pathways to produce advanced biofuels and approaches to reduce metabolite toxicity and cost and increase titre, rate and yield.

Jay Keasling
Hector Garcia Martin
Eric Sundstrom
Reviews25 Jun 2021
Nature Reviews Microbiology

Volume: 19, P: 701-715
Bayesian model and selection signature analyses reveal risk factors for canine atopic dermatitis

A genome-wide evaluation in four different dog breeds identifies multiple genomic regions that were significantly related to risk of atopic dermatitis, providing additional biological insights into disease pathogenesis in dogs.

Katarina Tengvall
Elisabeth Sundström
Kerstin Lindblad-Toh
ResearchOpen Access08 Dec 2022
Communications Biology

Volume: 5, P: 1-17
Individual participant data meta-analysis to compare EPDS accuracy to detect major depression with and without the self-harm item

Xia Qiu
Yin Wu
Kimberly A. Yonkers
ResearchOpen Access10 Mar 2023
Scientific Reports

Volume: 13, P: 1-12

Search

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

Man-made lakes and sea-level rise

Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits

T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV

Increased soldier production in ant colonies exposed to intraspecific competition

Defining the role of common variation in the genomic and biological architecture of adult human height

Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

Diminishing benefits of urban living for children and adolescents’ growth and development

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

Genetic studies of body mass index yield new insights for obesity biology

Inclusive fitness theory and eusociality

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Mediterranean diet and rheumatoid arthritis: A nine-year cohort study and systematic review with meta-analysis

Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

Short-chain ketone production by engineered polyketide synthases in Streptomyces albus

Repositioning of the global epicentre of non-optimal cholesterol

New genetic loci link adipose and insulin biology to body fat distribution

Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals

Genetic loci associated with heart rate variability and their effects on cardiac disease risk

Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Erratum: Genetic loci associated with heart rate variability and their effects on cardiac disease risk

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics

Microbial production of advanced biofuels

Bayesian model and selection signature analyses reveal risk factors for canine atopic dermatitis

Individual participant data meta-analysis to compare EPDS accuracy to detect major depression with and without the self-harm item

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