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Showing 1–3 of 3 results
Advanced filters: Author: Eric Valeur Clear advanced filters

  • Targeting the interaction between transcription factor TEAD and its co-repressor VGL4 is an attractive strategy to chemically modulate Hippo signaling. Here, the authors develop a proteomimetic with stabilized tertiary structure that inhibits the TEAD:VGL4 interaction in vitro and in cells.

    • Hélène Adihou
    • Ranganath Gopalakrishnan
    • Herbert Waldmann
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Recent advances in areas such as natural product biosynthesis, synthetic biology and the development of biosensors are providing new opportunities to directly harness evolutionary pressure to identify and optimize compounds with desired bioactivities. This article describes innovations in the key components of such strategies, highlights pioneering examples that indicate their potential, and discusses the scientific gaps and challenges that remain to be addressed to realize this potential more broadly in drug discovery.

    • Andrew M. Davis
    • Alleyn T. Plowright
    • Eric Valeur
    Reviews
    Nature Reviews Drug Discovery
    Volume: 16, P: 681-698