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Showing 1–3 of 3 results
Advanced filters: Author: Erica Houthuys Clear advanced filters

  • Metabolites in the tumor microenvironment, including adenosine, have been shown to suppress anti-tumor immune responses. Here, the authors show that T cell expression of the adenosine transporter ENT1 is involved in this immunosuppression and can be targeted to boost T cell function, tumor killing and immune checkpoint blockade.

    • Theodore J. Sanders
    • Christopher S. Nabel
    • Erica Houthuys
    ResearchOpen Access
    Nature Immunology
    Volume: 26, P: 854-865

  • The mammalian aryl hydrocarbon receptor (known to sense environmental pollutants) is shown to also have a role as a pattern recognition receptor in sensing bacterial virulence factors, resulting in an antibacterial response and activation of innate and natural defences.

    • Pedro Moura-Alves
    • Kellen Faé
    • Stefan H. E. Kaufmann
    Research
    Nature
    Volume: 512, P: 387-392