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Showing 1–9 of 9 results
Advanced filters: Author: Erick M. Carreira Clear advanced filters

  • Ameliorating or preventing signatures of aging in humans using natural compounds is an exciting area of research. Here the authors isolate a previously unknown phytochemical from carrots which activates defence mechanisms against oxidative stress and extends lifespan in worms, and improves glucose metabolism, promotes exercise capacity, and protects from frailty at higher age in mice.

    • Carolin Thomas
    • Reto Erni
    • Michael Ristow
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18

  • In silico chemical prediction of a polyketide synthase gene cluster in the bacterium Gynuella sunshinyii has led to the discovery of a class of natural products called janustatins. The absolute configuration of the stereocentres in these compounds was determined by a combination of techniques including DFT calculations and 2D NMR experiments—and finally confirmed by total synthesis. Janustatins were found to cause delayed, synchronized cell death at subnanomolar concentrations.

    • Reiko Ueoka
    • Philipp Sondermann
    • Jörn Piel
    Research
    Nature Chemistry
    Volume: 14, P: 1193-1201

  • Leucascandrolide A and neopeltolide are structurally related natural products with potent growth inhibitory activity. The synthesis of a designed analog of leucascandrolide A and its evaluation in a yeast haploinsufficiency screen has revealed the cytochrome bc1 complex as a molecular target of these compounds.

    • Karl-Heinz Altmann
    • Erick M Carreira
    News & Views
    Nature Chemical Biology
    Volume: 4, P: 388-389

  • This paper presents the total synthesis of a chlorosulpholipid cytotoxin, leading to confirmation of the proposed structure and the discovery of unanticipated reactivity of polychlorinated hydrocarbons. The concise synthetic approach should enable synthetic chemists to prepare sufficient quantities to facilitate biological studies.

    • Christian Nilewski
    • Roger W. Geisser
    • Erick M. Carreira
    Research
    Nature
    Volume: 457, P: 573-576

  • Stress-hormone receptors are important therapeutic targets for many diseases but the currently clinically approved inhibitor lacks specificity. Here the authors present a stress hormone receptor depletion tool that differs in its mode of action making it specific in counteracting the effects of stress.

    • Mahshid Gazorpak
    • Karina M. Hugentobler
    • Katharina Gapp
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-23

  • The spatial organization of cell surface receptors is critical for cell signaling and drug action. Here, the authors develop an optoproteomic method for mapping surface protein interactions, revealing cellular responses to antibodies, drugs and viral particles as well as immunosynapse signaling events.

    • Maik Müller
    • Fabienne Gräbnitz
    • Bernd Wollscheid
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Life- and healthspan of organisms can be modulated by dietary, genetic, or pharmacological interventions, which often affect metabolic pathways. Here the authors report that Grainyhead 1 is an evolutionarily conserved, drug-inducible transcription factor that promotes longevity in C. elegans, and thus a potential target for the development of geroprotective drugs.

    • Giovanna Grigolon
    • Elisa Araldi
    • Fabian Fischer
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • Technologies for identifying receptor-ligand pairs on living cells at physiological conditions remain scarce. Here, the authors develop a mass spectrometry-based ligand receptor capture technology that can identify receptors for a diverse range of ligands at physiological pH with as few as a million cells.

    • Nadine Sobotzki
    • Michael A. Schafroth
    • Bernd Wollscheid
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-8