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Showing 1–2 of 2 results
Advanced filters: Author: Erik Daa Funder Clear advanced filters

  • It is shown that zinc sulphinate salts can be used to transfer alkyl radicals to heterocycles, allowing for the mild, direct and operationally simple formation of medicinally relevant carbon–carbon bonds while reacting in a complementary fashion to other innate carbon–hydrogen functionalization methods.

    • Yuta Fujiwara
    • Janice A. Dixon
    • Phil S. Baran
    Research
    Nature
    Volume: 492, P: 95-99

  • Dimethyl fumarate (DMF) is a major drug in the treatment of psoriasis and multiple sclerosis. Here the authors reveal a mechanism of RSK/MSK inhibition through covalent inhibition that can explain the observed clinical effects and the dose–response characteristics of DMF treatment.

    • Jacob Lauwring Andersen
    • Borbala Gesser
    • Poul Nissen
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-8