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Showing 1–4 of 4 results
Advanced filters: Author: Erik Martinez-Hackert Clear advanced filters

  • Differentiation of human pluripotent stem cells (hPSC) mimics aspects of embryonic developmentin vitrobut is poorly understood. Here, the authors identify bulk cell density as a key parameter directing transition from pluripotency to primitive streak-like priming in hPSCs via secreted LEFTY/CERBERUS.

    • Henning Kempf
    • Ruth Olmer
    • Robert Zweigerdt
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • Here, the X-ray crystal structure of TrkH is solved, a protein that mediates potassium uptake in Vibrio parahaemolyticus, a bacterium. The selectivity filter of the ion transporter is very similar to what is seen in (much simpler) potassium ion channels, but it is significantly shorter. Biochemical studies were performed to explore the molecular basis of K+ selectivity, and it is believed that a novel gating mechanism is involved.

    • Yu Cao
    • Xiangshu Jin
    • Ming Zhou
    Research
    Nature
    Volume: 471, P: 336-340

  • Fortilin prevents the activation of the TGF-β1 receptor by occupying the pocket of TGF-β1 and competing with TGF-βRII to bind with TGF-β1. This inhibits Smad3 phosphorylation and the differentiation of C3H10T1/2 mesenchymal progenitor cells to smooth muscle cells.

    • Decha Pinkaew
    • Erik Martinez-Hackert
    • Ken Fujise
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-13