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Showing 1–2 of 2 results
Advanced filters: Author: Erin Schexnaydre Clear advanced filters

  • Structures of 5-lipoxygenase (5-LOX) reveal that NDGA disturbs regions that shield the active site while AKBA binds an allosteric site. NDGA inhibits 5-LOX activity using its redox-active function, while AKBA changes the enzyme’s regiospecificity

    • Nathaniel C. Gilbert
    • Jana Gerstmeier
    • Marcia E. Newcomer
    Research
    Nature Chemical Biology
    Volume: 16, P: 783-790

  • Here the authors combine a multimodal imaging-snRNAseq transcriptomics strategy to provide insight into the distribution of a neurotropic tick-borne flavivirus in the brain, and show that absence of interferon signaling increases infection of resident microglia.

    • Nunya Chotiwan
    • Ebba Rosendal
    • Anna K. Överby
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18