Taking advantage of DNA hybridization, we fabricated a series of nonarithmetic logic circuits on a simple and universal molecular beacon platform, including multiplexer, demultiplexer, encoder and decoder. Multiple fluorescence outputs were generated in parallel on the same set of inputs. The advantages of the enzyme-free DNA systems here include high flexibility, reconfigurability, massive parallelism and scalability, offering an opportunity to construct multi-component devices on a single biomolecular platform.
- Hailong Li
- Yaqing Liu
- Erkang Wang