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Showing 1–4 of 4 results
Advanced filters: Author: Eshan Ghosh Clear advanced filters

  • β-arrestins initially contact with the phosphorylated carboxyl-terminus of GPCRs before engaging with the GPCR core. Here, the authors use a chimeric GPCR partially and fully engaged with β-arrestin1 and show that the core interaction is dispensable for receptor endocytosis and signalling.

    • Punita Kumari
    • Ashish Srivastava
    • Arun K. Shukla
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-16

  • Biased signaling gives hormones, probes or drugs distinct functional outcomes via the same receptor. The Biased Signaling Atlas (https://BiasedSignalingAtlas.org) provides a community hub with data and tools to advance this paradigm, which may yield safer and more potent drugs.

    • Jimmy Caroli
    • Alibek Mamyrbekov
    • David E. Gloriam
    Comments & Opinion
    Nature Chemical Biology
    Volume: 19, P: 531-535

  • Considerable progress has been made in the past few years in our ability to visualize the structure of G protein-coupled receptors (GPCRs) and their signalling complexes. This is due to a series of technical improvements in areas such as protein engineering, lipidic cubic phase-based crystallization and microfocus synchrotron beamlines.

    • Eshan Ghosh
    • Punita Kumari
    • Arun K. Shukla
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 16, P: 69-81