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Showing 1–3 of 3 results
Advanced filters: Author: Esther Griesbach Clear advanced filters

  • H2A.X histone variant gene encodes poly(A)+ and poly(A)- mRNA isoforms which are differentially expressed depending on cell lines. Here the authors show that upon DNA damage, cells expressing more poly(A)+ isoform require this isoform for de novo H2A.X synthesis while cells with more poly(A)- isoform have sufficient H2A.X present in chromatin.

    • Esther Griesbach
    • Margarita Schlackow
    • Nick J. Proudfoot
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Schädli et al. present a bioreactor system that combines mechanical loading with longitudinal microCT imaging to assess bone mineralization in a poly(lactic-co-glycolic acid) (PLGA) scaffold reinforced with nanoparticles. This approach allows rapid and rigorous evaluation of engineered bone scaffolds performance in vitro and might reduce the use of animals for experimentation.

    • Gian Nutal Schädli
    • Jolanda R. Vetsch
    • Ralph Müller
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-14