TGF-β mediates epithelial-mesenchymal transitions (EMT) during tumorigenesis but the molecular mechanisms driving this effect have been unclear. The transcriptional repressor SNAIL1 and the downstream effector of TGF-β SMAD3/4 cooperate to repress gene expression during TGF-β-mediated EMT.
- Theresa Vincent
- Etienne P. A. Neve
- Jonas Fuxe