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Advanced filters: Author: Eugene Tkachenko Clear advanced filters

Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos

The mechanisms of sensing of blood flow and responses to it in vascular remodelling are poorly understood. Here, the authors show that in zebrafish blood flow controls both the fate determination of individual blood vessels and the arterial versus venous identity of endothelial cells lining them.

Bart Weijts
Edgar Gutierrez
Eugene Tkachenko
ResearchOpen Access14 Dec 2018
Nature Communications

Volume: 9, P: 1-11
Protein kinase A governs a RhoA–RhoGDI protrusion–retraction pacemaker in migrating cells

Live-cell imaging of the spatiotemporal kinetics of PKA activation during cell migration reveals that PKA regulates the protrusion and retraction cycle of the leading edge. Protrusion formation correlates with RhoA and PKA activation. PKA subsequently phosphorylates RhoA to increase its interaction with RhoGDI and terminate RhoA activity at the leading edge.

Eugene Tkachenko
Mohsen Sabouri-Ghomi
Mark H. Ginsberg
Research15 May 2011
Nature Cell Biology

Volume: 13, P: 660-667
Rigidity of silicone substrates controls cell spreading and stem cell differentiation

Grigory Vertelov
Edgar Gutierrez
Eugene Tkachenko
ResearchOpen Access21 Sept 2016
Scientific Reports

Volume: 6, P: 1-6

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