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Showing 1–9 of 9 results
Advanced filters: Author: Eulàlia de Nadal Clear advanced filters

  • Cells change gene expression in response to stress to promote survival. Here, the authors map the transcriptional dynamics of osmoadaptation in yeast, showing that isogenic populations respond to stress using different transcriptional strategies.

    • Mariona Nadal-Ribelles
    • Guillaume Lieb
    • Francesc Posas
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • By combining a yeast single-cell RNA-seq method that counts transcript start sites in a strand- and isoform-specific manner with index sorting, the authors uncover a linear relationship between cell size and RNA content and extreme cell heterogeneity in the expression of metabolic genes.

    • Mariona Nadal-Ribelles
    • Saiful Islam
    • Lars M. Steinmetz
    Research
    Nature Microbiology
    Volume: 4, P: 683-692

  • During S phase of the cell cycle, transcription and replication need to be coordinated in order to avoid conflicts leading to potential genomic instability. Here, the authors find that Mrc1 integrates signals from different kinases to regulate replication during unscheduled transcription events.

    • Alba Duch
    • Berta Canal
    • Francesc Posas
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • How cells shape signalling dynamics in MAPK cascades remains unclear. Here the authors combine mathematical modelling with in vivo validation to uncover a novel feedback mechanism that increases processivity and robustness of the yeast Hog1 module.

    • Maximilian Mosbacher
    • Sung Sik Lee
    • Manfred Claassen
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • For synthetic biologists' creativity to be unleashed, basic circuits must become truly interchangeable, that is, modular and scalable. This study, one of two linked papers, has harnessed yeast pheromone communication to achieve complex computation through communication between individual cells performing simple logic functions. Such extracellular 'chemical wiring' is one promising way to get around intracellular noise when building more complex genetic circuitry.

    • Sergi Regot
    • Javier Macia
    • Ricard Solé
    Research
    Nature
    Volume: 469, P: 207-211

  • Organisms are exposed to various stresses, and responding rapidly and appropriately to these changes is crucial for survival. This Review describes how gene expression is regulated at many levels in response to stresses, including through signalling to chromatin or affecting transcriptional machinery.

    • Eulàlia de Nadal
    • Gustav Ammerer
    • Francesc Posas
    Reviews
    Nature Reviews Genetics
    Volume: 12, P: 833-845