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Showing 1–2 of 2 results
Advanced filters: Author: Eunae Sandra Cho Clear advanced filters

  • Hippo and Wnt pathways are important for cancer development, and they can cross talk; however, the mechanisms behind this connection are unknown. Here the authors show that DVL (a scaffold protein in the Wnt pathway) regulates the shuttling of YAP (a key component of the Hippo pathway) between cytoplasm and nucleus in specific tumor suppressor contexts.

    • Yoonmi Lee
    • Nam Hee Kim
    • Jong In Yook
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16

  • Cancer cell survival under metabolic stress is a critical step for metastasis. Here, the authors show that under glucose deprivation, Snail, a key regulator of the metastatic process, promotes survival by diverting glucose to the pentose phosphate pathway through repression of phosphofructokinase PFKP.

    • Nam Hee Kim
    • Yong Hoon Cha
    • Hyun Sil Kim
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12