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This study reveals how genetic profiles shape brain structure, function, and behavior in over 8,600 children, linking polygenic scores to key brain imaging features and cognitive traits during early neurodevelopment.

Phosphatases are key components in cellular signalling networks. Here, the authors present a systematic functional analysis of phosphatases of the fungal pathogen Cryptococcus neoformans, revealing roles in virulence, stress responses, O-mannosylation, retromer function and other processes.

This study presents an ultracompact eye camera using a novel low aspect-ratio metalens design. Achieving a 120° field of view, the system enables high-performance gaze tracking and iris recognition, ideal for future augmented reality glasses.

Cryptococcus neoformans is the leading cause of death by fungal meningoencephalitis. Here, the authors study the roles played by 129 putative kinases in the growth and virulence of C. neoformans, identifying potential targets for development of anticryptococcal drugs.

The amount of genetic material that can be packaged in AAV vectors used for genome editing is limited. Here the authors show that the smallest known Cas9 orthologue, cjCas9, can be packaged in a single AAV vector along with sgRNA and a marker gene, and demonstrate efficient gene editing in mice.

Cryptococcus neoformans is a fungal pathogen that causes meningoencephalitis. Here the authors describe the production of a gene-deletion mutant collection representing most C. neoformansnon-essential transcription factors, providing insight into the signalling networks that govern the biology and pathogenicity of this fungus.

How glioblastoma stem cells (GSCs) and tumor-associated macrophages (TAMs) interact to promote progression of glioblastoma multiforme (GBM) is currently unclear. Here, the authors demonstrate a role for the ARS2/MAGL signalling in regulating self-renewal and tumorigenicity of GSCs and M2-like TAM polarization.

Hydrogels have a variety of applications including tissue engineering and controlled drug delivery. Here, liquid-crystal hydrogels are developed which transform into a fluid solution upon cooling; cells can be encapsulated in the gel at room temperature, then released at physiological temperatures.

Drosophila haemocytes collaborate with the tracheal system to reserve and transport oxygen through the phase transition of PPO2 crystals, facilitating internal oxygen homeostasis in a process that is comparable to vertebrate respiration.

SexSy is a promising positive electrode material for non-aqueous Li||chalcogen batteries. However, the behaviour of S and Se in the electrode is unclear. Here, the authors investigate the physicochemical phenomena of SexSy and the catalytic role of Se during battery testing.

The limited operational stability of multi-resonance thermally activated delayed fluorescence emitters often constrains their practical application. Here, the authors report a direct correlation between device lifetime and Faradaic yield for oxidative degradation of emitter molecules.

Brain organoids derived from human pluripotent stem cells can model human brain development and disease, though current culture systems fail to ensure reliable production of high-quality organoids. Here the authors combine human brain extracellular matrix and culture in a microfluidic device to promote structural and functional maturation of human brain organoids.

Ferroptosis is an iron-dependent cell death mechanism that is emerging as a target for cancer therapy. Here, the authors find that lipoprotein-associated phospholipase A2 modulates ferroptosis resistance by controlling phospholipid metabolism.

A human-AI collaborative computer vision algorithm produces grid-level economic statistics using satellite images and lightweight human annotation, revealing granular development patterns in North Korea and five other least developed Asian countries.

Hydrogels made from decellularized human brain tissue facilitate the direct conversion of primary mouse embryonic fibroblasts into induced neuronal cells that lead to therapeutic outcomes after transplantation in an animal model of ischaemic stroke.

The ability to recognize an individual and retrieve related information is crucial for social animals. Here, the authors employ a new social recognition paradigm to show that dorsal CA1 neurons distinguish individual mice and encode associated reward information.

Soft elastic materials could be useful in the fabrication of brain-machine interfaces, but achieving the desirable material properties can be challenging. Here, the authors report control of the amorphous-crystalline transition of polymers to alter hydrogel properties and monitor mouse behaviour.

A simple episomal fluorescent reporter for flow cytometric enrichment of cells with zinc-finger nuclease– or TALE nuclease–induced genomic modifications is described.

In the formation of physical hydrogels from triblock copolymers, formation of polymer loops can result in topological defects. Here, the authors report the development of hydrogels from oppositely charged copolymers which assembled to form branched and bridge-rich networks.

In vitro digestion of genomic DNA with Cas9 and single guide RNAs (sgRNAs) yields genome-wide off-target sites at frequencies below 0.1%. Off-target sites can be further reduced with modified sgRNAs.

The directional features of dipole moments of Frenkel excitons and exciplexes are important for optoelectronic applications. Here, the authors study photo- and electro-luminescence emissions of organic heterostructures and observe angular chromism of exciplexes, indicating possible delocalization.

Kim et al. found that visual inputs trigger gated feedforward inhibition of ACC neurons, which disinhibits striatal motor neurons and initiates precise responses in mice performing a visual Go/No-go task.

Undesired off-target effects can hamper the use of CRISPR-Cas9 in therapeutic applications. Here the authors use a directed evolution approach to develop Sniper-Cas9 which combines high specificity with no loss of on-target activity.

An array of 2D crystals of isotropic, 432-symmetric chiral gold nanoparticles is shown to exhibit collective resonances with a strong and uniform chiral near field, allowing enantioselective detection by the collective circular dichroism.

Creating durable, motion-compliant neural interfaces is essential for accessing dynamic tissues in vivo and linking neural activity with behaviors. Here, the authors introduce carbon nanotube-enhanced polyvinyl alcohol hydrogels, creating electrically anisotropic, fatigue-resistant fibers for long-term intraspinal electrophysiological recordings in mice.

ESRP1 is reported to regulate the alternative splicing of some genes involved in epithelial–mesenchymal transition. Here the authors show that LRRFIP2 is a target of ESRP1 and that two spliced variants of LRRFIP2 have opposing functions in gastric cancer metastasis

Randomness is perceived in two different extremes, in macroscopic homogeneity and local heterogeneity, but apparently far away from order. Here, the authors show that a periodic order can spontaneously arise from an ensemble of binary random copolymer sequences to induce recurrent folding of a self-assembled bilayer structure in water.

The limited efficacy of current immunotherapy suggests low antigen-specific T cells and immunosuppressive factors in tumor microenvironment (TME). Here, the authors develop a syringeable immunomodulatory multi-domain nanogel that can reprogram the TME and induce enhanced cancer immunotherapy.

Methane monooxygenase (MMO)—a protein of high biotechnological interest for the selective and mild conversion of methane to methanol—lacks a high-throughput production system. Now, the authors report the efficient production of particulate MMO-mimics for catalysis in solution and hydrogels.

Low-grade systemic inflammation and stress increase vulnerability to neuropsychiatric disorders. Here, the authors show that inflammation and stress-induced changes in higher order cognitive networks increase vulnerability to posttraumatic stress disorder.

Spatiotemporal control of intracellular molecular self-assembly holds promise for therapeutic applications. Here the authors develop a peptide consisting of a phenylalanine dipeptide with a mitochondrial targeting moiety to form self-assembling fibrous nanostructures within mitochondria, leading to apoptosis.

The protein levels of the tumour suppressor p53 can be negatively regulated by HDM2, which is an attractive target for cancer therapy. In this study, Lee et al. graft the transactivation domain of p53 onto a scaffold protein and show that this binds to HDM2 and inhibits cancer cell growth in vitro.

Next generation sequencing has difficulty in detecting rare-frequency variants due to high sequencing errors. Here the authors present a barcode-free error validation method that physically extracts erroneous reads to identify true variants.

DFT simulations may be inaccurate in modeling aqueous systems, with results depending on the choice of the exchange-correlation functional. Here, the authors present an integrative method called HF-r²SCAN-DC4 that provides near chemical accuracy in electronic structure information not only for pure water but also for molecules dissolved in it