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Showing 1–5 of 5 results
Advanced filters: Author: Eunjin Ryu Clear advanced filters

  • Replication-Factor-C (RFC) and RFC-like complexes (RLCs) mediate chromatin engagement of the proliferating cell nuclear antigen (PCNA). Here authors use biochemical and single molecule measurements to show that ATAD5-RLC has the most potent PCNA unloading activity and forms structurally distinct intermediates compared to RFC-PCNA.

    • Mi-Sun Kang
    • Eunjin Ryu
    • Kyungjae Myung
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • Regulation of PCNA ubiquitination is required for initiating lesion bypass and ensuring subsequent high-fidelity replication and ensure genome stability. Here, the authors reveal that BAZ1B inhibits ATAD5-UAF1-USP1, thereby preventing premature PCNA de-ubiquitination during lesion bypass under replicative stress.

    • Yeongjae Kim
    • Na Young Ha
    • Sukhyun Kang
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Selecting subsets of specific sequences from complex oligonucleotide libraries is crucial for genomics and data storage but faces scalability limits due to primer design constraints. Here, the authors present a barcode-based selection method that enables efficient, hierarchical, and programmable oligo subset retrieval.

    • Woojin Kim
    • Mingweon Chon
    • Yeongjae Choi
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-9

  • High-throughput sequencing is used to identify somatic variants in cancer patients. Here, the authors perform panel-based profiling of 5095 clinical samples and demonstrate that many clinically-actionable variants have low variant allele fractions, requiring assays with high detection sensitivity.

    • Hyun-Tae Shin
    • Yoon-La Choi
    • Woong-Yang Park
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10