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Showing 1–3 of 3 results
Advanced filters: Author: Eva Absmeier Clear advanced filters

  • Using cryo-EM, the authors show that the mammalian CCR4–NOT complex specifically recognizes stalled translating ribosomes similar to the yeast complex, locks them in a translation-incompetent state and coordinates their ubiquitylation, highlighting its central role in linking translation to mRNA stability.

    • Eva Absmeier
    • Viswanathan Chandrasekaran
    • Lori A. Passmore
    Research
    Nature Structural & Molecular Biology
    Volume: 30, P: 1314-1322

  • The DNA helicase ASCC3 is the largest subunit of the activating signal co-integrator complex (ASCC), and its DNA unwinding activity is required for the AlkBH3/ASCC-dependent DNA de-alkylation repair pathway. Here, the authors identify a minimal stable complex of the two ASCC subunits ASCC2 and ASCC3, determine the complex crystal structure and further show that cancer-related mutations at the interface between both proteins reduce ASCC2–ASCC3 affinity.

    • Junqiao Jia
    • Eva Absmeier
    • Markus C. Wahl
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13