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Showing 51–100 of 101 results

Advanced filters: Author: Eva Greiner Clear advanced filters

The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors

The E3-ubiquitin ligase APC/C and its cofactor Cdh1 have been shown to play important roles in axonal growth and synaptic plasticity. In this study, Eguren et al.show that elimination of Cdh1 in the developing nervous system results in defects in the neural progenitor compartment, hydrocephalus and reduced lifespan.

Manuel Eguren
Eva Porlan
Marcos Malumbres
Research04 Dec 2013
Nature Communications

Volume: 4, P: 1-16
Structure-based energetics of protein interfaces guides foot-and-mouth disease virus vaccine design

Foot-and-mouth disease virus (FMDV) capsids are often unstable, thus limiting their use as vaccines. A computational method was used to strengthen protein-protein interfaces and engineer stabilized FMDV capsids, which generated improved antibody responses in vaccinated calves and guinea pigs.

Abhay Kotecha
Julian Seago
David I Stuart
Research21 Sept 2015
Nature Structural & Molecular Biology

Volume: 22, P: 788-794
Swarming motility and biofilm formation of Paenibacillus larvae, the etiological agent of American Foulbrood of honey bees (Apis mellifera)

Anne Fünfhaus
Josefine Göbel
Elke Genersch
ResearchOpen Access11 Jun 2018
Scientific Reports

Volume: 8, P: 1-12
Comparison of ROTEM parameters from venous and intraosseous blood

Marion Wiegele
Thomas Hamp
Eva Schaden
ResearchOpen Access06 Mar 2019
Scientific Reports

Volume: 9, P: 1-7
Influence of the human papillomavirus on the radio-responsiveness of cancer stem cells in head and neck cancers

Paul Reid
Alexander H. Staudacher
Eva Bezak
ResearchOpen Access17 Feb 2020
Scientific Reports

Volume: 10, P: 1-8
Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis

Rogier Hintzen and colleagues report the results of a search for genetic variants associated with susceptibility to multiple sclerosis in a genetically isolated population that lead to identification of a new susceptibility locus in the region of the KIF1B gene on chromosome 1.

Yurii S Aulchenko
Ilse A Hoppenbrouwers
Rogier Q Hintzen
Research09 Nov 2008
Nature Genetics

Volume: 40, P: 1402-1403
Pharmacological blockade of cannabinoid receptor 2 signaling does not affect LPS/IFN-γ-induced microglial activation

Bolanle Fatimat Olabiyi
Anne-Caroline Schmoele
Andreas Zimmer
ResearchOpen Access10 Jul 2023
Scientific Reports

Volume: 13, P: 1-11
Crosstalk of injured podocytes with parietal epithelial cells through Wnt4/β-Catenin signaling

Eike Schwartze
Eva Pfister
Christoph Daniel
ResearchOpen Access04 Jun 2025
Scientific Reports

Volume: 15, P: 1-15
Evidence, detailed characterization and clinical context of complement activation in acute multisystem inflammatory syndrome in children

György Sinkovits
János Schnur
Zoltán Prohászka
ResearchOpen Access17 Nov 2022
Scientific Reports

Volume: 12, P: 1-18
One thousand plant transcriptomes and the phylogenomics of green plants

The One Thousand Plant Transcriptomes Initiative provides a robust phylogenomic framework for examining green plant evolution that comprises the transcriptomes and genomes of diverse species of green plants.

James H. Leebens-Mack
Michael S. Barker
Gane Ka-Shu Wong
ResearchOpen Access23 Oct 2019
Nature

Volume: 574, P: 679-685
The proteome of circulating extracellular vesicles and their functional effect on platelets vary with the isolation method

Eva M. Fernández-Sáez
Susana B. Bravo
Ángel García
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-14
Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry

Warwick B Dunn
David Broadhurst
Royston Goodacre
Protocols30 Jun 2011
Nature Protocols

Volume: 6, P: 1060-1083
Honing-in antigen-specific cells during antibody discovery: a user-friendly process to mine a deeper repertoire

The authors developed a methodology for bulk enrichment of antigen-specific B cells to improve the diversity of antibody sequences and increase the number of functional antigen-specific antibodies coming from different antibody generation platforms.

Ankit Mahendra
Aftabul Haque
Partha S. Chowdhury
ResearchOpen Access30 Oct 2022
Communications Biology

Volume: 5, P: 1-17
Sequential orthogonal assays for longitudinal and endpoint characterization of three-dimensional spheroids

The authors present a protocol for the self-assembly of single-cell suspensions into spheroids by the liquid overlay method, followed by a modular framework of orthogonal assays to phenotype spheroids both longitudinally and at an endpoint.

Eva Blondeel
Sam Ernst
Olivier De Wever
Protocols08 Apr 2025
Nature Protocols

Volume: 20, P: 2899-2941
Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer

The authors report the first-in-human application of personalized neo-antigen RNA vaccines in patients with melanoma.

Ugur Sahin
Evelyna Derhovanessian
Özlem Türeci
Research05 Jul 2017
Nature

Volume: 547, P: 222-226
CD14⁺CD16⁺ monocytes are the main target of Zika virus infection in peripheral blood mononuclear cells in a paediatric study in Nicaragua

The main targets of Zika virus infection in human peripheral blood mononuclear cells are monocytes, particularly CD14⁺CD16⁺ monocytes, which are expanded in Zika patients and in in vitro-infected samples.

Daniela Michlmayr
Paulina Andrade
Eva Harris
Research02 Oct 2017
Nature Microbiology

Volume: 2, P: 1462-1470
A 3D primary human cell-based in vitro model of non-alcoholic steatohepatitis for efficacy testing of clinical drug candidates

Simon Ströbel
Radina Kostadinova
Eva Thoma
ResearchOpen Access23 Nov 2021
Scientific Reports

Volume: 11, P: 1-18
Single-cell transcriptomics following ischemic injury identifies a role for B2M in cardiac repair

Molenaar et al. use scRNA-seq to profile cardiac cell gene expression changes at three time points following ischemic injury. They observe that B2M is secreted by cardiomyocytes following injury, promoting scar formation. This data may be useful in finding therapeutic targets for cardiac repair

Bas Molenaar
Louk T. Timmer
Eva van Rooij
ResearchOpen Access29 Jan 2021
Communications Biology

Volume: 4, P: 1-15
Fenretinide induces a new form of dynamin-dependent cell death in pediatric sarcoma

Eva Brack
Marco Wachtel
Beat W. Schäfer
Research06 Mar 2020
Cell Death & Differentiation

Volume: 27, P: 2500-2516
Effect of Spheroidal Age on Sorafenib Diffusivity and Toxicity in a 3D HepG2 Spheroid Model

Christoph Eilenberger
Mario Rothbauer
Seta Küpcü
ResearchOpen Access19 Mar 2019
Scientific Reports

Volume: 9, P: 1-11
Development of a miniaturized 96-Transwell air–liquid interface human small airway epithelial model

Teresa Bluhmki
Sarah Bitzer
Ralf Heilker
ResearchOpen Access03 Aug 2020
Scientific Reports

Volume: 10, P: 1-14
Newcastle disease virus infection induces B7-1/B7-2-independent T-cell costimulatory activity in human melanoma cells

Christian C Termeer
Volker Schirrmacher
Jürgen C Becker
Research24 May 2000
Cancer Gene Therapy

Volume: 7, P: 316-323
Augmentation of wastewater-based epidemiology with machine learning to support global health surveillance

Wastewater-based epidemiology has already proven to be a powerful tool to monitor the spread of a number of diseases. This Perspective discusses the integration with machine learning, highlighting its potential in a number of wastewater-based epidemiology applications.

Eva Aßmann
Timo Greiner
Christopher Irrgang
Reviews02 Jun 2025
Nature Water

Volume: 3, P: 753-763
In vitro model of retinoblastoma derived tumor and stromal cells for tumor microenvironment (TME) studies

Emily Alefeld
André Haase
Maike Anna Busch
ResearchOpen Access18 Dec 2024
Cell Death & Disease

Volume: 15, P: 1-12
Effect of hypercholesterolemia on circulating and cardiomyocyte-derived extracellular vesicles

Csenger Kovácsházi
Szabolcs Hambalkó
Zoltán Giricz
ResearchOpen Access26 May 2024
Scientific Reports

Volume: 14, P: 1-14
Antibodies against apoB100 peptide 210 inhibit atherosclerosis in apoE^-/- mice

Pontus Dunér
Ingrid Yao Mattisson
Eva Bengtsson
ResearchOpen Access27 Apr 2021
Scientific Reports

Volume: 11, P: 1-10
St. John's wort extract Ze 117 alters the membrane fluidity of C6 glioma cells by influencing cellular cholesterol metabolism

Swen Bremer
Eva Weitkemper
Sebastian Franken
ResearchOpen Access30 Apr 2024
Scientific Reports

Volume: 14, P: 1-13
The addition of bortezomib to rituximab, high-dose cytarabine and dexamethasone in relapsed or refractory mantle cell lymphoma—a randomized, open-label phase III trial of the European mantle cell lymphoma network

Luca Fischer
Linmiao Jiang
Martin Dreyling
ResearchOpen Access27 Apr 2024
Leukemia

Volume: 38, P: 1307-1314
GDAP1 loss of function inhibits the mitochondrial pyruvate dehydrogenase complex by altering the actin cytoskeleton

GDAP1 mutations effect Charcot-Marie-Tooth disease 4A by inhibiting the pyruvate dehydrogenase complex and restricting mitochondrial localization of dynamin-related protein 1 through alterations of the actin cytoskeleton.

Christina Wolf
Alireza Pouya
Axel Methner
ResearchOpen Access03 Jun 2022
Communications Biology

Volume: 5, P: 1-15
Transplanting rejuvenated blood stem cells extends lifespan of aged immunocompromised mice

Sara Montserrat-Vazquez
Noelle J. Ali
M. Carolina Florian
ResearchOpen Access29 Dec 2022
npj Regenerative Medicine

Volume: 7, P: 1-17
The catalytic subunit of Plasmodium falciparum casein kinase 2 is essential for gametocytogenesis

Hitz et al. describe the role of the protein kinase PfCK2α in the development of the human malaria parasite Plasmodium falciparum. Using mutant parasites, they show that PfCK2α is not only essential for asexual but also sexual development of P. falciparum blood stage parasites, and hence it may hold promise as a potential target for antimalarial drugs.

Eva Hitz
Olivia Grüninger
Till S. Voss
ResearchOpen Access12 Mar 2021
Communications Biology

Volume: 4, P: 1-15
Functional human iPSC-derived alveolar-like cells cultured in a miniaturized 96‑Transwell air–liquid interface model

Teresa Bluhmki
Stefanie Traub
Ralf Heilker
ResearchOpen Access23 Aug 2021
Scientific Reports

Volume: 11, P: 1-19
Extraction of highly degraded DNA from ancient bones, teeth and sediments for high-throughput sequencing

This protocol update describes silica-based approaches for purification of DNA from ancient bone, tooth and sediment samples. The optimized buffers yield short DNA fragments compatible with high-throughput sequencing library preparation.

Nadin Rohland
Isabelle Glocke
Matthias Meyer
Protocols15 Oct 2018
Nature Protocols

Volume: 13, P: 2447-2461
Mapping in vivo target interaction profiles of covalent inhibitors using chemical proteomics with label-free quantification

This protocol describes the identification of in vivo target interaction profiles of covalent enzyme inhibitors using chemical proteomics. Enzymes are enriched by activity-based probes and quantified by label-free mass spectrometry.

Eva J van Rooden
Bogdan I Florea
Mario van der Stelt
Protocols22 Mar 2018
Nature Protocols

Volume: 13, P: 752-767
Steroid hormone-related polymorphisms associate with the development of bone erosions in rheumatoid arthritis and help to predict disease progression: Results from the REPAIR consortium

Jose M. Sánchez-Maldonado
Rafael Cáliz
Juan Sainz
ResearchOpen Access15 Oct 2019
Scientific Reports

Volume: 9, P: 1-16
Functional detection of botulinum neurotoxin serotypes A to F by monoclonal neoepitope-specific antibodies and suspension array technology

Laura von Berg
Daniel Stern
Brigitte G. Dorner
ResearchOpen Access02 Apr 2019
Scientific Reports

Volume: 9, P: 1-14
The codon sequences predict protein lifetimes and other parameters of the protein life cycle in the mouse brain

Sunit Mandad
Raza-Ur Rahman
Eugenio F. Fornasiero
ResearchOpen Access15 Nov 2018
Scientific Reports

Volume: 8, P: 1-19
NFKB2 polymorphisms associate with the risk of developing rheumatoid arthritis and response to TNF inhibitors: Results from the REPAIR consortium

Jose Manuel Sánchez-Maldonado
Manuel Martínez-Bueno
Juan Sainz
ResearchOpen Access09 Mar 2020
Scientific Reports

Volume: 10, P: 1-13
Choosing the Right Differentiation Medium to Develop Mucociliary Phenotype of Primary Nasal Epithelial Cells In Vitro

Anja E. Luengen
Caroline Kniebs
Anja Lena Thiebes
ResearchOpen Access24 Apr 2020
Scientific Reports

Volume: 10, P: 1-11
Establishing reference ranges of cord blood: point-of-care hemostatic function assessment in preterm and term neonates

Marion Wiegele
Oliver Kimberger
Lydia Triffterer
Research18 Dec 2020
Pediatric Research

Volume: 90, P: 452-458
The impact of circulating preeclampsia-associated extracellular vesicles on the migratory activity and phenotype of THP-1 monocytic cells

Árpád Ferenc Kovács
Orsolya Láng
Éva Pállinger
ResearchOpen Access03 Apr 2018
Scientific Reports

Volume: 8, P: 1-12
Nucleosome stability measured in situ by automated quantitative imaging

László Imre
Zoltán Simándi
Gábor Szabó
ResearchOpen Access06 Oct 2017
Scientific Reports

Volume: 7, P: 1-15
“TORNADO” – Theranostic One-Step RNA Detector; microfluidic disc for the direct detection of microRNA-134 in plasma and cerebrospinal fluid

Hazel McArdle
Eva M. Jimenez-Mateos
Elaine Spain
ResearchOpen Access11 May 2017
Scientific Reports

Volume: 7, P: 1-11
Cell death stages in single apoptotic and necrotic cells monitored by Raman microspectroscopy

Eva Brauchle
Sibylle Thude
Katja Schenke-Layland
ResearchOpen Access15 Apr 2014
Scientific Reports

Volume: 4, P: 1-9
Low-density lipoprotein mimics blood plasma-derived exosomes and microvesicles during isolation and detection

Barbara W Sódar
Ágnes Kittel
Edit Irén Buzás
ResearchOpen Access18 Apr 2016
Scientific Reports

Volume: 6, P: 1-12
Electron microscopy of cardiac 3D nanodynamics: form, function, future

In this Review, the authors discuss the latest insight into the 3D nanostructure of the heart and how deformation during contraction and relaxation affects cellular function. They also describe technological breakthroughs in biological sample preparation, 3D imaging and data analysis with electron microscopy.

Peter Kohl
Joachim Greiner
Eva A. Rog-Zielinska
Reviews08 Apr 2022
Nature Reviews Cardiology

Volume: 19, P: 607-619
Multiplex amplification of ancient DNA

Holger Römpler
Paul H Dear
Michael Hofreiter
Protocols13 Jul 2006
Nature Protocols

Volume: 1, P: 720-728
Genome-wide association analysis for chronic venous disease identifies EFEMP1 and KCNH8 as susceptibility loci

Eva Ellinghaus
David Ellinghaus
Andre Franke
ResearchOpen Access04 Apr 2017
Scientific Reports

Volume: 7, P: 1-9
In-depth Temporal Transcriptome Profiling of Monkeypox and Host Cells using Nanopore Sequencing

Balázs Kakuk
Ákos Dörmő
Zsolt Boldogkői
ResearchOpen Access09 May 2023
Scientific Data

Volume: 10, P: 1-12
Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity

L O'Leary
A M van der Sloot
E Szegezdi
Research08 Jun 2015
Oncogene

Volume: 35, P: 1261-1270

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