Roquin proteins mediate the degradation of mRNAs through the recognition of stem-loop structures present within their 3′ UTR. Here Schuetz et al. present the crystal structure of a Roquin domain and, through complementary biochemical analyses, provide insight into Roquin's mode of RNA binding through a winged helix-turn-helix motif.
- Anja Schuetz
- Yasuhiro Murakawa
- Udo Heinemann