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Showing 1–14 of 14 results
Advanced filters: Author: Evan Spruijt Clear advanced filters

  • The surface charge and ζ-potential of biomolecular condensates is key to their interactions with membranes and proteins. Here, the authors developed a method to determine the ζ-potential of condensates using microelectrophoresis and single-droplet tracking.

    • Merlijn H. I. van Haren
    • Brent S. Visser
    • Evan Spruijt
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-10

  • Coacervate droplets are promising protocells that sequester nutrients, but how new peptides could be synthesized inside coacervates remains a mystery. Here, the authors develop redox-active coacervates that facilitate the formation of new peptide bonds.

    • Jiahua Wang
    • Manzar Abbas
    • Evan Spruijt
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11

  • Active coacervate droplets are droplets coupled to a chemical reaction that maintains them out of equilibrium, which can be used to drive active processes, but coacervates are still subject to passive processes that compete with or mask growth. Here, the authors present a nucleotide-based model for active coacervate droplets that form and grow by fuel-driven synthesis of ATP, and, importantly, do not undergo Ostwald ripening.

    • Karina K. Nakashima
    • Merlijn H. I. van Haren
    • Evan Spruijt
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • Liquid–liquid phase separation plays an important role in creating cellular compartments and protocells, but designing small-molecule models remains difficult. A peptide-based synthon for liquid–liquid phase separation consisting of two stickers and a flexible, polar spacer has now been presented. Condensates formed by these synthons can concentrate biomolecules and catalyse anabolic reactions.

    • Manzar Abbas
    • Wojciech P. Lipiński
    • Evan Spruijt
    Research
    Nature Chemistry
    Volume: 13, P: 1046-1054

  • Peptides are small yet versatile building blocks of biomaterials. This Comment highlights recent progress in the design of liquid-like microdroplets, or coacervates, based on peptides and produced through liquid–liquid phase separation. This emerging platform holds promise as efficacious delivery vehicles for multi-purpose biomedical applications.

    • Jianhui Liu
    • Evan Spruijt
    • Robert Langer
    Comments & Opinion
    Nature Reviews Materials
    Volume: 8, P: 139-141

  • Biomolecular condensates help organize cell components under normal conditions but can also be involved in pathological protein aggregation when condensate proteins carry mutations or under stress conditions. This Review discusses the possible mechanisms behind such aggregation processes that potentially lead to neurodegenerative diseases.

    • Brent S. Visser
    • Wojciech P. Lipiński
    • Evan Spruijt
    Reviews
    Nature Reviews Chemistry
    Volume: 8, P: 686-700

  • Communications Chemistry is delighted to introduce a Collection of articles that combine coacervation with systems chemistry. Here, the Guest Editors of the Collection introduce the importance of research at the interface between these two topics and highlight the current challenges in this area.

    • Lorraine Leon
    • Guillermo Monreal Santiago
    • Evan Spruijt
    EditorialOpen Access
    Communications Chemistry
    Volume: 7, P: 1-2

  • Liquid-liquid phase separation (LLPS) underlies the formation of intracellular membraneless compartments in biology and may have played a role in the formation of protocells that concentrate key chemicals during the origins of life. While LLPS of simple systems, such as oil and water, is well understood, many aspects of LLPS in complex, out-of-equilibrium molecular systems remain elusive. Here, the author discusses open questions and recent insights related to the formation, function and fate of such condensates both in cell biology and protocell research.

    • Evan Spruijt
    Comments & OpinionOpen Access
    Communications Chemistry
    Volume: 6, P: 1-5