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Showing 1–2 of 2 results
Advanced filters: Author: Evanthia Pashos Clear advanced filters

  • UCN2 acts as a ligand for the GPCR CRHR2 and there have been conflicting reports on whether UCN2 treatment improves or worsens glucose tolerance. Here, the authors show that acute UCN2 recruits Gs and decreases glucose uptake, while chronic treatment desensitizes CRHR2 and improves glucose uptake.

    • Stephen E. Flaherty III
    • Olivier Bezy
    • Zhidan Wu
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • The bone morphogenetic protein (BMP) 9/10 receptor, ALK1, was recently shown to mediate LDL entry and transcytosis in endothelial cells. Here, Lee et al. show that genetic ablation of arterial endothelial ALK1 in mice limits atherosclerosis without affecting cholesterol or triglyceride levels and that a monoclonal antibody binding ALK1 efficiently blocks LDL transcytosis, but not BMP9 signaling, leading to a reduction in plaque burden.

    • Sungwoon Lee
    • Hubertus Schleer
    • William C. Sessa
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 2, P: 438-448