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Showing 1–4 of 4 results

Advanced filters: Author: Evelyn Dixit Clear advanced filters

Diverse intracellular pathogens activate type III interferon expression from peroxisomes

Type III interferons have important antiviral functions, but they are poorly described compared to type I interferons. Kagan and colleagues demonstrate that type III interferons are induced on peroxisomes in response to a variety of viral triggers.

Charlotte Odendall
Evelyn Dixit
Jonathan C Kagan
Research22 Jun 2014
Nature Immunology

Volume: 15, P: 717-726
An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

The identity of the cytoplasmic DNA receptor that activates the inflammasome has remained elusive. Superti-Furga and colleagues use a proteomics screen to identity AIM2 as the DNA sensor for the inflammasome.

Tilmann Bürckstümmer
Christoph Baumann
Giulio Superti-Furga
Research21 Jan 2009
Nature Immunology

Volume: 10, P: 266-272
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

Dying tumor cells release ATP, which activates the NLRP3 inflammasome in dendritic cells, enabling the secretion of interleukin-1β and the subsequent priming of tumor-specific interferon-γ-producing T lymphocytes.

François Ghiringhelli
Lionel Apetoh
Laurence Zitvogel
Research20 Sept 2009
Nature Medicine

Volume: 15, P: 1170-1178