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Showing 1–2 of 2 results
Advanced filters: Author: Ewald T J van den Bremer Clear advanced filters

  • Although never demonstrated in humans, exchange of the antigen-binding regions of IgG4 antibodies with different specificities could complicate certain antibody therapies. Labrijn et al. show that Fab-arm exchange occurs in patients and propose that a single mutation can inhibit the process.

    • Aran F Labrijn
    • Antonio Ortiz Buijsse
    • Paul W H I Parren
    Research
    Nature Biotechnology
    Volume: 27, P: 767-771

  • Labrijn et al. describe the generation of bispecific antibodies through controlled Fab-arm exchange, involving separate expression of two parental IgG1s containing single matching point mutations, followed by recombination of the 'half molecules'.

    • Aran F Labrijn
    • Joyce I Meesters
    • Paul W H I Parren
    Protocols
    Nature Protocols
    Volume: 9, P: 2450-2463