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Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis

Impaired oligodendrocyte (OL) differentiation and remyelination after myelin damage in multiple sclerosis is associated with neurodegeneration. The authors show that Gsta4 is expressed during adult OL differentiation and identify it as a regulator of OL differentiation, survival, and remyelination.

Karl E. Carlström
Keying Zhu
Fredrik Piehl
ResearchOpen Access13 Aug 2020
Nature Communications

Volume: 11, P: 1-13
Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes

Dimethyl fumarate (DMF) is an established treatment for relapsing multiple sclerosis with unclear mechanism of action. Here the authors distinguish DMF responders by monocyte counts and redox gene signature in a prospective longitudinal cohort at 3 month of therapy, and associate NOX3 genetic variants with outcome.

Karl E. Carlström
Ewoud Ewing
Fredrik Piehl
ResearchOpen Access12 Jul 2019
Nature Communications

Volume: 10, P: 1-13
Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells

Brain microglial cells can be replenished by blood-derived monocytes, but many aspects of this repopulation remain unclear. Here the authors show that the brain microglial niche can be replaced both by proliferating, residential microglia as well as differentiated Ly6C^hi monocytes, with the latter having overlapping but distinct characteristics.

Harald Lund
Melanie Pieber
Robert A. Harris
ResearchOpen Access19 Nov 2018
Nature Communications

Volume: 9, P: 1-13
DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis

The human leukocyte antigen (HLA) haplotype DRB1*15:01 is the major risk factor for multiple sclerosis (MS). Here the authors find that DNA methylation at HLA-DRB1 gene mediates the effect of DRB1*15:01 and of a protective HLA variant on HLA-DRB1 expression and the risk of MS.

Lara Kular
Yun Liu
Maja Jagodic
ResearchOpen Access19 Jun 2018
Nature Communications

Volume: 9, P: 1-15
Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling

Harris and colleagues show that the cytokine TGF-β is required for colonization of the microglial niche and maintenance of central nervous system integrity. Acute loss of TGF-β leads to proinflammatory responses and fatal demyelinating disease.

Harald Lund
Melanie Pieber
Robert A. Harris
Research16 Apr 2018
Nature Immunology

Volume: 19, P: 1-7
Non-parametric combination analysis of multiple data types enables detection of novel regulatory mechanisms in T cells of multiple sclerosis patients

Sunjay Jude Fernandes
Hiromasa Morikawa
David Gomez-Cabrero
ResearchOpen Access19 Aug 2019
Scientific Reports

Volume: 9, P: 1-12

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Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis

Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes

Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells

DNA methylation as a mediator of HLA-DRB115*:01 and a protective variant in multiple sclerosis

Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling

Non-parametric combination analysis of multiple data types enables detection of novel regulatory mechanisms in T cells of multiple sclerosis patients

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Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis

Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes

Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells

DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis

Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling

Non-parametric combination analysis of multiple data types enables detection of novel regulatory mechanisms in T cells of multiple sclerosis patients

Search

Quick links

DNA methylation as a mediator of HLA-DRB115*:01 and a protective variant in multiple sclerosis