Fluorinated ketones can function as covalent warheads applied in the design of reversible covalent inhibitors, however, the reactivity of certain fluorinated moieties remains underexplored. Here, the authors investigate the species-specific lipophilicities of fluorinated geminal diketones in multicomponent equilibrium systems and reveal their potential as multifaceted warheads for reversible covalent drugs.
- Ishay Columbus
- Lee Ghindes-Azaria
- Yossi Zafrani
