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Showing 1–2 of 2 results
Advanced filters: Author: Eyla C. Arteaga Clear advanced filters

  • The APC/C ubiquitylates histones to regulate gene expression in pluripotent cells. Here, the authors pair cryo-EM and biochemical and biophysical assays to show that instead of modifying nucleosome-incorporated histones, the APC/C ubiquitylates extranucleosomal histone complexes through a mechanism that bypasses canonical substrate degrons.

    • Aleksandra Skrajna
    • Tatyana Bodrug
    • Robert K. McGinty
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Spangler et al. used a substrate inhibitor covalent conjugate strategy to solve cryo-EM structures of nucleosomes in complex with the lysine demethylase KDM2, which demonstrates that KDM2A, but not its closely related paralog, KDM2B, anchors to the acidic patch to direct histone H3K36-specific demethylation.

    • Cathy J. Spangler
    • Aleksandra Skrajna
    • Robert K. McGinty
    Research
    Nature Chemical Biology
    Volume: 19, P: 624-632