Neutrophil activation has been shown to rely on the pentose phosphate pathway (PPP) for NADPH generation and reactive oxygen species production. In this study, the authors identify a mechanism of neutrophil activation that is independent of the PPP but relies on the glycolytic enzyme pyruvate kinase M2 instead.
- Juliana Escher Toller-Kawahisa
- Carlos Hiroji Hiroki
- José Carlos Alves-Filho
