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Showing 1–2 of 2 results
Advanced filters: Author: Félix Weis Clear advanced filters

  • The deamination of all adenosines in the wobble base position is essential to empower the individual tRNA to decode several codons. Here, the authors present the cryo-EM structure of the tRNA-bound ADAT2/3 deaminase, revealing how the geometry-specific enzyme acquiesces sequence-divergent tRNAs to its active site.

    • Luciano G. Dolce
    • Aubree A. Zimmer
    • Eva Kowalinski
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • During eukaryotic ribosome biogenesis, the nascent 60S subunit is activated by SBDS and GTPase EFL1. Cryo-EM and mutational analyses reveal how SBDS–EFL1 evicts antiassociation factor eIF6 from 60S and explain the effects of disease-related SBDS mutations.

    • Félix Weis
    • Emmanuel Giudice
    • Alan J Warren
    Research
    Nature Structural & Molecular Biology
    Volume: 22, P: 914-919