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Showing 1–2 of 2 results
Advanced filters: Author: Fa-Ke Lu Clear advanced filters

  • Despite major drug discovery efforts, the therapeutic options for glioblastoma (GBM) remain inadequate. Here they analyze patient-derived xenograft model of GBM to quantitatively map distribution and cellular response to the EGFR inhibitor erlotinib, and report heterogeneous erlotinib delivery to intracranial tumors to be inadequate to inhibit EGFR signaling.

    • Elizabeth C. Randall
    • Kristina B. Emdal
    • Nathalie Y. R. Agar
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • Sensitive and label-free imaging methods to visualize nerve degeneration are currently lacking. Here authors show that stimulated Raman scattering (SRS) microscopy can be used to monitor peripheral nerve degeneration in mouse models of amyotrophic lateral sclerosis (ALS) and in postmortem tissue from ALS patients.

    • Feng Tian
    • Wenlong Yang
    • Kevin Eggan
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-15